End Point

Exposure Data

Species and Reference

Uncertainty Factors

Acceptable Concentrations

Species

Small n

1 h

24 h

7 d

30 d

180 d

Hyperventilation

 

 

 

 

 

 

 

 

 

Tolerability

NOAEL at 2%, 24 h/d, 11 or 30 d

Human (n = 4, 4, 6) (Sinclair et al. 1969; Radziszewski et al. 1988; Guillerm and Radziszewski 1979)

10/(14)½

0.7

0.7

0.7

Exercise impairment

NOAEL at 2%, 24 h/d, 5, 15, or 30 d

Human (n = 6, 4, 6) (Glatte et al. 1967; Sinclair et al. 1971; Radziszewski et al. 1988)

10/(16)½

0.8

0.8

0.8

Testicular injury

NOAEL at 3%, 24 h/d, 42 d

Rat and guinea pig (Schaefer et al. 1971)

1

3

3

3

SMAC 1996

 

 

 

 

1.3

1.3

0.7

0.7

0.7

Source: Wong 1996.



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