The following HTML text is provided to enhance online
readability. Many aspects of typography translate only awkwardly to HTML.
Please use the page image
as the authoritative form to ensure accuracy.
Medical Isotope Production without Highly Enriched Uranium
Direct-use material: Material that is directly usable in nuclear weapons. Such materials include highly enriched uranium (HEU) and separated plutonium.
Dissolution: The process of putting a material into solution.
Downblend: Dilution of HEU with depleted uranium or natural uranium to convert it into low enriched uranium (LEU).
Drug master file (DMF): A document submitted to the Food and Drug Administration (FDA) by a Mo-99 producer describing the facility in which the Mo-99 is made; the production process itself, including any raw materials used in production; and product test methods, specifications, stability, and release criteria that may be used as a source of information when FDA approval is sought.
Eluting: Recovering an isotope (Tc-99m) by passing a saline solution through the alumina column of the generator.
Enriched uranium: Uranium with a higher concentration of the U-235 isotope than found naturally.
Enrichment: Process used to increase the concentration of the uranium-235 (U-235) isotope in a material relative to U-238.
Fission: Process whereby a large atomic nucleus (such as uranium) is split into two (and sometimes three) smaller nuclei.
Fission cross-section: Probability that a nucleus will capture a neutron and fission, usually expressed in barns.
Fission fragments: Smaller atomic fragments resulting from fission of a large nucleus.
Formula quantities: Special nuclear material in strategic quantities. For HEU this quantity is greater than 5 kg.
Greater-Than-Class-C waste: Radioactive waste that contains concentrations of certain radionuclides above the Class C limits in 10 CFR §61.55.
Greenfield construction: Construction of new facilities for producing and/or processing Mo-99.
Half-life: The time required for a quantity of radioactive material to decay to half of its initial value.
High-level waste: Highly radioactive materials containing fission products and transuranic elements produced as a byproduct of the reactions that occur inside nuclear reactors.
Highly enriched uranium: Uranium enriched to concentrations greater than or equal to 20 percent by weight of U-235.
Hot cell: Shielded workspace for working with highly radioactive materials.