for Mo-99 could be slightly higher than the 2006 estimates provided by the NNSA and ANSTO (2007) report. However, because of supply disruptions in 2007 and 2008 that were described in Chapter 4, it is not likely that all of the demand for Mo-99 in 2008 had been met.


The projected demand for Mo-99 is of great interest to both current producers and to potential new producers. Future demand is unknowable in a strictly quantitative sense because it will be determined by events that have yet to occur and that cannot necessarily be predicted. Several factors that could affect projected demand growth are discussed in the following sections of this chapter.

The committee used several sources of information to develop projected demand estimates for this report, including published estimates, estimates provided to the committee at its information-gathering sessions, and commercial market analyses. Some of the projected demand information gathered by the committee was provided under nondisclosure agreements. The committee has not disclosed any proprietary information in this report, but it has used proprietary information to “ground truth” its projected demand estimates.

The information sources used to develop demand growth estimates are not strictly independent. The commercially available market analyses are based on information provided by Mo-99 producers, technetium generator manufacturers, pharmaceutical companies, and hospitals. Mo-99 producers and technetium generator manufacturers use these market analyses and other information to develop their own projected demand estimates for business planning purposes. Consequently, there is likely to be some circularity of information and reasoning reflected in these various estimates.

A commercial market analysis prepared by Bio-Tech Systems, Inc. (Bio-Tech Systems, 2006)1 provides a detailed assessment of future demand for Tc-99m. These estimates are based on the analysis of the radiopharmaceutical market, including the potential penetration of alternate imaging modalities that could substitute for Tc-99m in diagnostic imaging, as well as the impacts of demographic changes on the demand for imaging procedures. Demand for Tc-99m is an accurate indicator of Mo-99 demand


The National Academies, at the committee’s request, purchased the global rights to this report. The committee was not able to evaluate the methods or data used by Bio-Tech Systems to develop the estimates contained in this report and therefore cannot vouch for their accuracy. However, based on conversations with industry representatives, the committee judges that this report is generally viewed as an authoritative and valuable source of information on the diagnostic radiopharmaceutical market. The report is available in the public access file for this study.

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