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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

Support for this project was provided by the National Library of Medicine and the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (Award Number N01-OD-04-2139, Task Order 182); the National Science Foundation (Award Number CNS-0638373); the Vanderbilt University Medical Center; Partners HealthCare System; the Robert Wood Johnson Foundation (Award Number 59392); and the Commonwealth Fund (Award Number 20070083). Any opinions expressed in this material are those of the authors and do not necessarily reflect the views of the agencies and organizations that provided support for the project.

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