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Appendix A Agenda Microbial Evolution and Co-Adaptation: A Workshop in Honor of Joshua Lederberg May 20-21, 2008 The National Academies 500 Fifth Street, NWâRoom 100 Washington, DC DAY 1: MAY 20, 2008 9:00-9:30: Registration and continental breakfast 9:30-9:45: Welcoming remarks Forum Leadership 9:45-10:45: Reflections on the life and scientific legacies of Josh Lederberg Moderator: Margaret âPeggyâ Hamburg, M.D., Nuclear Threat Initiative ⢠David A. Hamburg, M.D. Carnegie Corporation ⢠Stephen S. Morse, Ph.D. Columbia University 10:45-11:15: Questions from Forum members and audience 11:15-11:30: Break 11:30-12:30: Lunch and continuation of Day 1 morning discussion
MICROBIAL EVOLUTION AND CO-ADAPTATION Session I The Microbiome and Co-Evolution Moderator: Jo Handelsman, Ph.D., University of Wisconsin, Madison 12:30-1:00: Evolutionary and ecological processes that shape natural microbial communities Jill Banfield, Ph.D. University of California, Berkeley 1:00-1:30: Plant-microbe symbioses: the good, the bad, and the cheater! Jean-Michel Jean-Michel Ané, Ph.D. University University of Wisconsin, Madison 1:30-2:00: The experimental deciphering of the complex molecular dialogue between host and bacterial symbiont Margaret McFall-Ngai, Ph.D. University of Wisconsin, Madison 2:00-2:30: War and peace: humans and their microbiome David Relman, M.D. Stanford University 2:30-3:15: Questions from Forum members and audience 3:15-3:30: Break Session II Microbial Evolution and the Emergence of Virulence Moderator: P. Frederick Sparling, Ph.D., University of North Carolina, Chapel Hill 3:30-4:00: A schizophrenic view of bacterial pathogenicity Stanley Falkow, Ph.D. Stanford University 4:00-4:30: Recent evolution in invasive salmonellosis Gordon Dougan, Ph.D. The Sanger Institute
APPENDIX A 4:30-5:00: Whole genome analysis of pathogen evolution Julian Parkhill, Ph.D. The Sanger Institute 5:00-5:30: The evolution of virulence in bacteria and viruses: an opinionated rant Bruce Levin, Ph.D. Emory University 5:30-6:00: Questions from Forum members and audience 6:15: AdjournâDay 1 7:00-9:00: Dinner with speakers and Forum members and continuing discussion of Day 1 DAY 2: MAY 21, 2008 8:30-9:00: Continental breakfast 9:00-9:15: Summary of Day 1 David Relman, M.D. Chair, Forum on Microbial Threats 9:15-9:45: Further reflections on Josh Lederbergâs life and legacies Adel Mahmoud, M.D., Ph.D. Princeton University Session III Mechanisms of Resistance Moderator: Steven Brickner, Ph.D., Pfizer, Inc. 9:45-10:15: Microbial drug resistance: an old problem that requires new solutions Stanley N. Cohen, M.D. Stanford University 10:15-10:45: Antibiotic resistance and the future of antibiotics Julian Davies, Ph.D. University of British Columbia 10:45-11:00: Break
MICROBIAL EVOLUTION AND CO-ADAPTATION 11:00-11:30: Expanding the resistance universe with metagenomics Jo Handelsman, Ph.D. University of Wisconsin, Madison 11:30-12:15: Questions from Forum members and audience 12:15-1:00: Lunch and continuation of Day 2 morning discussion Session IV Anticipation of Future Emerging Infectious Diseasesâ Is the Past, Prologue? Moderator: Stanley Lemon, M.D., University of Texas, Galveston 1:00-1:30: Emerging infections: condemned to repeat? Stephen S. Morse, Ph.D. Columbia University 1:30-2:00: Can we predict future trends in disease emergence? Peter Daszak, Ph.D. Consortium for Conservation Medicine, Wildlife Trust 2:00-2:30: Pathogen emergence: ecology or evolution? Mark Woolhouse, Ph.D. University of Edinburgh 2:30-3:00: Genomic evolvability and the origin of novelty Jonathan Eisen, Ph.D. University of California, Davis 3:00-3:30: Questions from Forum members and audience 3:30-4:00: Open discussion and wrap-up 4:00: Adjourn
