oxidizers, 69, 73, 96, 98, 120, 128-129, 131, 138, 188

peroxidizables, 72, 134, 139

radioactive mixtures, 202, 203, 205

rules for working with, 301

scrubbers, 236

spills, 28, 120

storage, 20, 96, 97, 98, 99, 100, 125

testing with, 188, 189

waste management, 196, 202, 203, 204, 205, 209, 210, 301

Acquisition of chemicals

CHP component, 295, 297, 298

compressed gases, 89, 140, 164-165

computerized, 88, 89

controlled substances, 261

cost containment, 5, 92

donations and gifts, 87, 92

just-in-time deliveries, 43, 89

minimization, 5, 21, 84, 164, 186

monitoring, 16, 19

ordering, 21, 86, 88-89

receiving, 21, 79, 89-90, 263, 278, 299

in smaller containers, 86

standards for, 21, 22, 278, 299

Acrolein, 60, 70, 303, CD

Acrylamide, CD

Acrylonitrile, 112, 273, 303, CD

Action levels, 16, 123, 269, 289, 292, 293-294

Activated carbon, 73, 136, 204, 231, 236

Acute toxicity (see also Allergens, sensitizers, and allergic reactions; Corrosives and corrosivity; Irritants)

aquatic, 50

defined, 59

dose-response relationships, 54

employee protection standards, 274, 275, 290, 293, 295, 301-302

empty containers, 191

examples of highly toxic compounds, 56, 60, 275, 301

exposure factors, 60

information sources, 48, 50, 51, 59

lethal dose/lethal concentration, 54-55, 59, 60, 275

oven drying of samples, 156-157

“particularly hazardous substances,” 55, 59, 274-275

risk assessment, 54, 55, 59-60

signs and symptoms, 19, 123, 137, 141

storage of chemicals, 97, 101

systemic effects, 59

waste regulation, 277

Administration and supervision (see also Chemical Hygiene Officers; Chemical Hygiene Plan; Documentation and record keeping; Inspections and audits)

chemical hygiene responsibilities, 15, 16, 17, 18, 22, 24, 297, 298-299

and culture of safety, 2, 3, 5, 7

emergency preparedness, 39, 42, 117, 178, 180, 281, 299

hazard controls, 14, 18, 19, 24, 108, 142

hazard evaluation and risk assessment, 47, 55, 60, 66, 75, 108, 123, 131, 301

laboratory supervisor, 17, 22, 24, 26, 75, 117, 177, 178, 180, 231, 297-298, 299

management of chemicals, 84, 123, 173

OSHA recommendations for, 296-300

reporting to supervisors, 15, 16, 17, 226, 301

security, 123, 145, 262

statutory requirements, 279, 280, 281, 295

waste management, 209, 302

Adverse reactions, 271, 279

Aerosols

biological hazards, 60, 126, 221

defined, 57

in environmental rooms, 245

filters and scrubbers, 124, 236, 301, 302-303

flammable, 50, 99, 290

housekeeping and, 114

inhalation, 57-58, 110, 221

monitoring, 144

radioactive, 204, 208, 221

risk assessment, 55, 60, 80, 221

suppression, 114, 124, 126, 208, 236, 240, 244, 301, 302-303

Air (see also Hot air; Respirators; Ventilation and environmental control systems)

autooxidation, 136

cleanliness in clean rooms, 244

compressed, 145, 165, 171, 180-181

dispersion modeling, 124

filters, 124, 126, 142, 143, 178, 179, 221, 236

liquefied, 69, 135, 138

motors, 151, 154

pollutants, 86, 234, 235-236

pressure control, 214, 219, 240

reactivity in, 70, 72, 87, 93, 125, 130, 134, 135, 136, 137, 139, 140, 141, 143, 160, 173

showers, 244

supply, 179, 180-181, 217, 222, 226, 227, 241

Airborne contaminants (see also Exhaust systems; Filters and filtration)

action levels, 269

in chemical hoods, 291

dry materials, 144

evaluating exposure, 209

explosive limits, 65, 66-67

lethal (LC) values, 56

monitoring, 60, 143, 144, 208, 228, 298

nanoparticles in, 135, 143, 144, 248

particulate materials, 57

pressure buildup and, 135

preventing exposure, 107, 178, 219, 296

protection against, 127, 144, 178-180

risk assessment, 219

skin exposure, 179

threshold limits, 60

vapor pressure and, 57

ventilation systems and, 219, 221, 241, 251, 296, 298

ALARA (as low as reasonably achievable) principle, 82, 219, 221

Alarms

audibility in environmental rooms, 245, 299

building code requirements, 218

in chemical hoods, 169, 226, 250



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