Research for Health identified a need for a workshop to examine existing systems that could be adapted to evaluate the clinical use and impact of genetically based innovations in patient care.1 Established in 2007, the Roundtable seeks to foster dialogue and partnerships that will advance the field of genomics and improve the translation of basic genomic research to health care, education, and health policy. On February 12, 2009, the Roundtable convened a workshop designed to address four central questions related to the development of systems to evaluate clinical use of health care innovations that stem from genome-based research:
What are the practical realities of creating such systems?
What different models could be used?
What are the strengths and weaknesses of each model?
How effectively can such systems address questions about health outcomes?
The following chapters summarize the presentations by the expert panelists, and the open discussions moderated by Roundtable Chair Wylie Burke. Chapter 2 provides an overview describing how the evidence needed for decision making may vary according to the particular application of the genome-based intervention. Chapters 3 through 5 summarize the three panel sessions: creating evidence systems; current practices in moving from evidence to decision; and gaps in the system for evaluation of genome-based health care. Closing remarks are provided in Chapter 6, and the workshop agenda and biographical sketches of the panelists are available in the appendixes.
The planning committee’s role was limited to planning the workshop. This workshop summary has been prepared by a rapporteur as a factual summary of what occurred at the workshop. Statements and opinions are those of individual presenters and participants, and should not be construed as reflecting any group consensus.