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TABLE A5-6 Virus Titres in Organs of Infected Miniature Pigsa

 

Virus titres (log10 PFU/g) of infected animals with:

A/California/04/09 (H1N1)

A/swine/Hokkaido/2/81 (H1N1)

Animal ID

#1

#2

#5

#6

Nasal mucosa

6.7

5.0

5.1

4.8

Oro/nasopharynx

3.1

3.3

6.8

5.0

Tonsil

3.2

b

4.5

4.4

Trachea

6.3

5.5

5.8

5.3

Bronchus (right)

5.6

6.1

5.9

6.5

Bronchus (left)

6.7

6.5

5.4

6.3

Lung (upper right)

7.8

6.6

6.1

4.5

Lung (middle right)

7.5

6.7

6.1

5.5

Lung (lower right)

6.4

6.8

5.3

4.5

Lung (upper left)

6.8

6.4

6.8

5.1

Lung (middle left)

8.0

7.6

4.7

5.5

Lung (lower left)

6.2

7.4

5.5

4.7

Ileum

3.5

Jejunum

2.8

aSpecific-pathogen free miniature pigs were intranasally infected with 106.2 PFU (1 ml) of virus. Two animals from each group were euthanized on day 3 pi for virus titration. No virus was recovered from heart, spleen, kidneys, liver, duodenum, rectum, bladder, cerebrum, cerebellum, or brain stem.

b—. virus not detected (detection limit: 2.0 log10 PFU/g).

TABLE A5-7 Virus Titres in Nasal Swabs from Infected Miniature Pigsa

 

 

Virus titers (log10 PFU/ml) of infected animals with:

A/California/04/09 (H1N1)

A/swine/Hokkaido/2/81 (H1N1)

Animal ID

 

#1

#2

#3

#4

#5

#6

#7

#8

 

Day 1

5.6

6.5

6.4

6.1

6.3

5.3

3.6

4.1

 

Day 2

6.5

6.5

7.4

6.7

5.5

5.5

5.1

5.6

 

Day 3

5.7

5.3

7.2

5.3

5.0

4.4

4.7

5.5

 

Day 4

 

 

3.7

3.6

 

 

4.9

4.6

 

Day 5

 

 

4.5

5.4

 

 

2.7

3.2

 

Day 6

 

 

4.3

5.3

 

 

2.8

3.2

 

Day 7

 

 

3.3

3.4

 

 

1.3

1.6

 

Day 8

 

 

b

 

 

 

Day 9

 

 

 

 

aMiniature pigs were intranasally infected with 106.2 PFU of virus (1 ml) of virus.

b —. virus not detected (detection limit: 1.0 log10 PFU/ml).

Blank: not applicable, animals euthanized on day 3 pi.



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