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TABLE A5-8 Virus Susceptibility to Antiviral Compounds in Cell Culture

 

IC90

A/California/04/09 (H1N1)

A/Kawasaki/UTK-4/09 (H1N1)

A/Kawasaki/UTK-23/08 (H1N1)

Oseltamivir carboxylatea

10.56c

2971.30

5.58

Zanamivir

17.67

42.33

21.93

R-125489b

4.24

11.70

10.17

T-705

0.16

0.23

0.13

aOseltamivir carboxylate is the active form of oseltamivir.

bR-125489 is the active form of CS-8958.

cIC90 value: mean µg/ml or nM of triplicate reactions for T-705 and other compounds tested, respectively.

TABLE A5-9 Virus Sensitivity in Neuraminidase Assays

 

IC50

A/California/04/09 (H1N1)

A/Osaka/164/09 (H1N1)

A/Kawasaki/UTK-4/09 (H1N1)

A/Kawasaki/UTK-23/08 (H1N1)

Oseltamivir carboxylatea

0.96c

1.6

1313

1.88

Zanamivir

0.32

0.43

0.79

0.36

R-125489b

0.41

0.44

0.34

0.20

aOseltamivir carboxylate is the active form of oseltamivir.

bR-125489 is the active form of CS-8958.

cIC50 value: mean nM of duplicate reactions.



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