. "A14 Origins and Evolutionary Genomics of the 2009 Swine-Origin H1N1 Influenza A Epidemic." The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic: Global Challenges, Global Solutions: Workshop Summary. Washington, DC: The National Academies Press, 2010.
The following HTML text is provided to enhance online
readability. Many aspects of typography translate only awkwardly to HTML.
Please use the page image
as the authoritative form to ensure accuracy.
The Domestic and International Impacts of the 2009-H1N1 Influenza a Pandemic: Global Challenges, Global Solutions - Workshop Summary
Notably, for the PB1,HA and M genes, some of these newly generated sequences are more similar to the S-OIV epidemic than any previously reported isolates (Supplementary Fig. A14-3). Notably, seven out of eight genomic segments found in a single 2004 isolate (Sw/HK/915/04 (H1N2)) were located in a sister lineage to the current outbreak. Not only does this suggest that the precursors of S-OIV were swine viruses, but also that they were geographically widely distributed. Crucially, however, the observation of a sister relationship between the current outbreak virus and Sw/HK/915/04 cannot be interpreted as evidence for a Eurasian origin of the outbreak, owing to the long branch of the phylogeny leading to the 2009 human strains (Fig. A14-2 and Table A14-1). This
FIGURE A14-2 Genetic relationships and timing of S-OIV for each genomic segment. Symbols represent sampled viruses on a timescale of when they were sampled and coloured by host species (pigs, red; humans, blue; birds, green). Internal nodes are reconstructed common ancestors with 95% credible intervals on their date given by the red bars. The S-OIV outbreak strains are represented by a blue triangle, with the apex representing the common ancestor of these.