The National Academies Press | Open Book THE NATIONAL ACADEMIES PRESS | OPENBOOK
  • Items in cart [0]

    • TABLE 4-6 Nervous System Diseases

    Study

    Design

    Population

    Outcomes

    Results

    Adjustments

    Comments

    Peripheral Neuropathy and Myopathy

    Davis et al., 2004 (Vol. 4)

    Cross-sectional, prevalence, medical evaluation, exposure-specific component

    1047 deployed veterans vs 1121 nondeployed veterans; 240 Khamisiyah-exposed deployed veterans vs 807 non-Khamisiyah-exposed deployed veterans

    Distal symmetric polyneuropathy identified by nerve-conduction studya

    Deployed vs nondeployed veterans: OR 0.65 (95% CI 0.33-1.28); Khamisiyah-exposed veterans vs non-Khamisiyah-exposed veterans: OR 1.04 (95% CI 0.25-4.37)

    Excludes coexisting conditionsb

    Low participation rate: 53% in deployed veterans, 39% in nondeployed veterans

    Rose et al., 2004; Sharief et al., 2002 (Vol. 4)

    Case-control

    49 symptomatic deployed UK veterans vs 26 healthy deployed UK veterans, 13 symptomatic Bosnia deployed veterans, 22 symptomatic Gulf War-era veterans

    Nerve-conduction studies, quantitative sensory and autonomic testing, concentric needle and single-fiber, electromyography, ischemic forearm exercise test, subanaerobic bicycle exercise test, muscle biopsy

    No significant differences between symptomatic deployed and nondeployed veterans, except deployed veterans had increased lactate production in bicycle exercise test

     

    Positive finding from bicycle test could reflect mitochondrial damage or inactivity resulting from ill health

    Kelsall et al., 2005 (Update)

    Cross-sectional survey

    1382 Australian male GWVs, 1376 nondeployed male era veterans frequency matched by age and service type (Same study population as Kelsall et al., 2004a,b)

    Self-reported neurologic symptoms corroborated during neurological examination; SF-12; modified NIS

    Lower limb neurological type symptoms and signs: OR 1.6 (95% CI 1.0-2.7) Neuropathy Score: GWV (2.0, sd = 4.3) vs controls (2.0, sd = 4.7) RoM 1.1 (95% CI 0.9-1.3) Association of neurological symptoms in self-reported nonexposed compared to exposed: PB (RoM 1.5, 95% CI 1.2-1.8)

    Antibiological warfare

    Age, rank, service type, current marital status, highest level of education, alcohol consumption, and history of diabetes

    Exposure data self-reported; response rate 80.5% for deployed, 56.8% for nondeployed


    The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
    Copyright © National Academy of Sciences. All rights reserved.
    Terms of Use and Privacy Statement