NAKFI Synthetic Biology: Building a Nation's Inspiration: Interdisciplinary Research Team Summaries

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Table of Contents
Front Matter R1-R14
Conference Summary 1-6
IDR Team Summary 1: What new foundational technologies and tools are required to make biology easier to engineer? 7-18
IDR Team Summary 2: What are the significant differences, if any, between risk assessment capacity and religious analyses of the moral permissibility for synthetic biology applications and other biotechnology applications? 19-24
IDR Team Summary 3: Reconstructing gene circuitry: How can synthetic biology lead us to an understanding of the principles underlying natural genetic circuits and to the discovery of new biology? 25-36
IDR Team Summary 4: Designing communities of cells: how do we create communication and collaboration between cells to allow for specialization and division of labor? 37-44
IDR Team Summary 5: Why are human-designed biological circuits and devices fragile and inaccurate relative to their natural counterparts? 45-52
IDR Team Summary 6: How can genomics be leveraged to develop coherent approaches for rapidly exploring the biochemical diversity in and engineering of non-model organisms? 53-60
IDR Team Summary 7: How do we move beyond genetics to engage chemical and physical approaches to synthetic biology? 61-70
IDR Team Summary 8: What is the role of evolution and evolvability in synthetic biology? 71-76
IDR Team Summary 9: How do we maximally capitalize on the promise of synthetic biology? 77-82
Appendixes 83-84
List of Synthetic Biology Podcast Tutorials 85-88
Agenda 89-94
Participants 95-106

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	Wendell A. Lim, Professor, Departments of Pharmacology and Biochemistry, University of California, San Francisco; Investigator, Howard Hughes Medical Institute
9:45 – 10:00 a.m.	Interdisciplinary Research Team and Grant Program Overview (Bonnie Bassler)
10:00 – 10:30 a.m.	Break
	IDR Team Starters Meet to Review Assignments
10:30 a.m. – 12:00 p.m.	Panel Discussion Moderator Joe Palca, Host of NAKFI’s Preconference Podcast Tutorials Panelists Frances H. Arnold (NAS/NAE/IOM), Dick and Barbara Dickinson Professor of Chemical Engineering and Biochemistry, California Institute of Technology Michael Elowitz, Assistant Professor of Biology and Applied Physics at the California Institute of Technology David A. Tirrell (NAS/NAE), Ross McCollum-William H. Corcoran Professor and former Chairman, Division of Chemistry and Chemical Engineering, California Institute of Technology Laurie Zoloth, Director, Center for Bioethics, Science, and Society, Northwestern University
12:00 – 1:00 p.m.	Lunch
1:00 – 5:00 p.m.	Interdisciplinary Research Team Session 1
3:00 – 3:30 p.m.	Break

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