Relevance of the intervention on a large scale

• Generalizability

Likelihood of achieving the expected outcomes in different demographic groups and in different communities/regions

• Sustainability

Likelihood that the intervention effect will last more than 1 to 5 years in the various groups

• Stakeholder acceptance

Likelihood that the intervention be well received by the target population/community and program delivery personnel

Costs and benefits of large-scale implementation

• Cost-effectiveness

Costs of the intervention versus measured effects on the outcomes of interest (e.g., premature deaths averted, years of life saved, pounds lost) compared with other competitive interventions

• Cost/benefit

Value of health benefits versus the costs of implementation compared with other competitive interventions

• Cost feasibility

Costs of implementing the intervention on a communitywide scale compared with other competitive interventions

• Cost minimization

Costs of implementing the intervention in a hospital compared with costs of implementing a competitive intervention in a community clinic and achieving the same outcome

• Cost utility

Stakeholder preferences versus implementation costs compared with other competitive interventions

Political and practical concerns

• Implementation priorities

Fit of the intervention with community or policy priorities; basis for giving this intervention high priority

• Portfolio balance

Fit within an overall set of interventions if considerations of feasibility, size of impact, and certainty of effect are combined

• Strategic planning

Strategies and tactics that can be used to mount this intervention