References
Altmann, L., A. Bottger, and H. Wiegand. 1990. Neurophysiological and psychophysical measurements reveal effects of acute low-level organic solvent exposure in humans. Int. Arch. Occup. Environ. Health 62(7):493-499.
Altmann, L., H. Wiegand, A. Bottger, F. Elstermeier, and G. Winneke. 1992. Neurobehavioral and neurophysiological outcomes of acute repeated perchloreothylene exposure. Appl. Psychol. 41(3):269-279.
Altmann, L., H.F. Neuhann, U. Kramer, J. Witten, and E. Jermann. 1995. Neurobehavioral and neurophysiological outcome of chronic low-level tetrachloroethene exposure measured in neighborhoods of dry cleaning shops. Environ. Res. 69(2):83-89.
Anders, M.W., L. Lash, W. Dekant, A.A. Elfarra, and D.R. Dohn. 1988. Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. Crit. Rev. Toxicol. 18(4):311-341.
Andersen, M.E., H.J. Clewell, III, M.L. Gargas, F.A. Smith, and R.H. Reitz. 1987. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87(2):185-205.
Anttila, A., E. Pukkala, M. Sallmen, S. Hernberg, and K. Hemminki. 1995. Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J. Occup. Environ. Med. 37(7):797-806.
Aschengrau, A., D. Ozonoff, C. Paulu, P. Coogan, R. Vezina, T. Heeren, and Y. Zhang. 1993. Cancer risk and tetrachloroethylene-contaminated drinking water in Massachusetts. Arch. Environ. Health 48(5):284-292.
ATSDR (Agency for Toxic Substances and Disease Registry). 1997. Toxicological Profile for Trichloroethylene (Update). U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA. September 1997 [online]. Available: http://www.atsdr.cdc.gov/toxprofiles/tp19-p.pdf [accessed Oct. 13, 2009].
Austin, E.W., J.M. Parrish, D.H. Kinder, and R.J. Bull. 1996. Lipid peroxidation and formation of 8-hydroxydeoxyguanosine from acute doses of halogenated acetic acids. Fundam. Appl. Toxicol. 31(1):77-82.
Beliles, R.P., D.J. Brusick, and F.J. Mecler. 1980. Teratogenic-Mutagenic Risk of Workplace Contaminants: Trichloroethylene, Perchloroethylene and Carbon Disulfide. NTIS Publication No. PB-82 185-075. NIOSH Contract Report No. 201-77-0047. Prepared by Litton Bionetics, Inc., for U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Cincinnati, OH.
Benignus, V.A., P.J. Bushnell, W.K. Boyes, C. Eklund, and E.M. Kenyon. 2009. Neurobehavioral effects of acute exposure to four solvents: Meta-analyses. Toxicol. Sci. 109(2):296-305.
Bhattacharya, R.K., and M.O. Schultze. 1971. Properties of DNA isolated from tissues of calves treated with S-(1,2-dichlorovinyl)-L-cysteine. II. Primer-template activity for bacterial DNA polymerases. Arch. Biochem. Biophys. 145(2):575-582.
Bhattacharya, R.K., and M.O. Schultze. 1972. Properties of DNA treated with S-(1,2-dichlorvinyl)-L-cysteine and a lyase. Arch. Biochem. Biophys. 153(1):105-115.
Birner, G., A. Rutkowska, and W. Dekant. 1996. N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: Two novel metabolites of tetrachloroethene in humans after occupational exposure. Drug Metab. Dispos. 24(1):41-48.
Birner, G., U. Bernauer, M. Werner, and W. Dekant. 1997. Biotransformation, excretion and nephrotoxicity of haloalkane-derived cysteine S-conjugtes. Arch. Toxicol. 72(1):1-8.
Blair, A., S.A. Petralia, and P.A. Stewart. 2003. Extended mortality follow-up of a cohort of dry cleaners. Ann. Epidemiol. 13(1):50-56.
Bloom, D.L., D.M. Byrne, and J.M. Andreson. 1993. Communicating Risk to Senior EPA Policy-Makers: A Focus Group Study. Prepared by Bloom Research and the Office of Air Quality Planning and Standards. U.S. Environmental Protection Agency, Research Triangle Park, NC.
Boice, J.D., Jr., D.E. Marano, J.P. Fryzek, C.J. Sadler, and J.K. McLaughlin. 1999. Mortality among aircraft manufacturing workers. Occup. Environ. Med. 56(9):581597.
Bois, F.Y., A. Gelman, J. Jiang, D.R. Maszle, L. Zeise, and G. Alexeef. 1996. Population toxicokinetics of tetrachloroethylene. Arch. Toxicol. 70(6):347-355.
Bolt, H.M., R.J. Laib, and J.G. Filser. 1982. Reactive metabolites and carcinogenicity of halogenated ethylenes. Biochem. Pharmacol. 31(1):1-4.
Boyes, W.K., M. Bercegeay, W.M. Oshiro, Q.T. Krntz, E.M. Kenyon, P.J. Bushnell, and V.A. Benignus. 2009. Acute perchloroethylene exposure alters rat visual-evoked potentials in relation to brain concentrations. Toxicol. Sci. 108(1):159-172.
Briving, C., I. Jacobson, A. Hamberger, P. Kjellstrand, K.G. Haglid, and L.E. Rosengren. 1986. Chronic effects of perchloroethylene and trichloroethylene on the gerbil brain amino acids and glutathione. Neurotoxicology 7(1):101-108.
Brodkin, C.A., W. Daniell, H. Checkoway, D. Echeverria, J. Johnson, K. Wang, R. Sohaey, D. Green, C. Redlich, D. Gretch, and L. Rosenstock. 1995. Hepatic ultrasonic changes in workers exposed to perchloroethylene. Occup. Environ. Med. 52(10):679-685.
Bull, R.J., I.M. Sanchez, M.A. Nelson, J.L. Larson, and A.L. Lansing. 1990. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology 63(3):341-359.
Bull, R.J., G.A. Orner, R.S. Cheng, L. Stillwell, A.J. Stauber, L.B. Sasser, M.K. Lingohr, and B.D. Thrall. 2002. Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol. Appl. Pharmacol. 182(1): 55-65.
Bull, R.J., L.B. Sasser, and X.C. Lei. 2004. Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice. Toxicology 199(2-3):169-183.
Bushnell, P.J., and K.M. Crofton. 1999. Organic solvents. Pp 394-428 in Introduction to Neurobehavioral Toxicology: Food and Environment, R.J.M. Niesink, R.M.A.
Jaspers, L.M.W. Kornet, J.M. van Ree, and H.A. Tilson, eds. Boca Raton, FL: CRC Press.
Bushnell, P.J., W.K. Boyes, T.J. Shafer, A.S. Bale, and V.A. Benignus. 2007. Approaches to extrapolating animal toxicity data on organic solvents to public health. Neurotoxicology 28(2):221-226.
Bushinsky, D.A., F.L. Coe, and O.W. Moe. 2008. Nephrolithiasis. Pp. 1299-1349 in Brenner and Rector’s The Kidney, 8th Ed. Philadephia, PA: Saunders.
Caldwell, D.J. 1999. Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk: a case study using alkyl phthalates. Regul. Toxicol. Pharmacol. 30(1):45-53.
Carney, E.W., B.A. Thorsrud, P.H. Dugard, and C.L. Zablotny. 2006. Developmental toxicity studies in Crl:CD (SD) rats following inhalation exposure to trichloroethylene and perchloroethylene. Birth Defects Res. B Dev. Reprod. Toxicol. 77(5):405-412.
Cavalleri, A., F. Gobba, M. Paltrinieri, G. Fantuzzi, E. Righi, and G. Aggazzotti. 1994. Perchloroethylene exposure can induce colour vision loss. Neurosci. Lett. 179(1-2):162-166.
Cederberg, H., J. Henriksson, and M.L. Binderup. In press. DNA damage detected by the alkaline comet assay in the liver of mice after oral administration of tetrachloroethylene. Mutagenesis.
Chiu, W.A., and F.Y. Bois. 2006. Revisiting the population toxicokinetics of tetrachloroethylene. Arch. Toxicol. 80(6):382-385.
Chiu, W.A., S. Micallef, A.C. Monster, and F.Y. Bois. 2007. Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in humans at 1 ppm: Empirical results and comparisons with previous studies. Toxicol. Sci. 95(1):23-36.
Costa, A.K., and K.M. Ivanetich. 1984. Chlorinated ethylenes: Their metabolism and effect on DNA repair in rat hepatocytes. Carcinogenesis 5(12):1629-1636.
Costa, L.G.., M. Aschner, A. Vitalone, T. Syversen, and O.P. Soldin. 2004. Developmental neuropathology of environmental agents. Annu. Rev. Pharmacol. Toxicol. 44:87-110.
Costantini, A.S., L. Miligi, D. Kriebel, V. Ramazzotti, S. Rodella, E. Scarpi, E. Stagnaro, R. Tumino, A. Fontana, G. Masala, C. Vigano, C. Vindigni, P. Crosignani, A. Benvenuti, and P. Vineis. 2001. A multicenter case-control study in Italy on hematolymphpoietic neoplasms and occupation. Epidemiology 12(1):78-87.
Cullen, A.C., and H.C. Frey. 1999. Probabilistic Exposure Assessment: A Handbook for Dealing with Variability and Uncertainty in Models and Inputs. New York: Plenum Press.
Dallas, C.E., X.M. Chen, K. O’Barr, S. Muralidhara, P. Varkonyi, and J.V. Bruckner. 1994. Development of a physiologically based pharmacokinetic model for perchloroethylene using tissue concentration-time data. Toxicol. Appl. Pharmacol. 128(1):50-59.
Dallas, C.E., X.M. Chen, S. Muralidhara, P. Varkonyi, R.L. Tackett, and J.V. Bruckner. 1995. Physiologically based pharmacokinetic model useful in prediction of the influence of species, dose, and exposure route on perchoroethylene pharmacokinetics. J. Toxicol. Environ. Health 44(3):301-317.
Dekant, W., M. Metzler, and D. Henschler. 1986a. Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity. J. Biochem. Toxicol. 1(2):57-72.
Dekant, W., M. Metzler, and D. Henschler. 1986b. Identification of S-1,2-dichlorovinylN-acetyl-cysteine as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats. Biochem. Pharmacol. 35(15):24552458.
Dekant, W., S. Vamvakas, H. Berthold, S. Schmidt, D. Wild, and D. Henschler. 1986c. Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. Chem. Biol. Interact. 60(1):31-45.
Dekant, W., K. Berthold, S. Vamvakas, D. Henschler, and M.W. Anders. 1988. Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate beta-lyase. Chem. Res. Toxicol. 1(3):175-178.
Dekant, W., G. Birner, M. Werner, and J. Parker. 1998. Glutathione conjugation of perchloroethene in subcellular fractions from rodent and human liver and kidney. Chem. Biol. Interact. 116(1-2):31-43.
DeMarini, D.M., E. Perry, and M.L. Shelton. 1994. Dichloroacetic acid and related compounds: Induction of prophage in E. coli and mutagenicity and mutation spectra in Salmonella TA100. Mutagenesis 9(5):429-437.
Doherty, A.T., S. Ellard, E.M. Parry, and J.M. Parry. 1996. An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. Mutagenesis 11(3):247-274.
Dosemeci, M., P. Cocco, and W.H. Chow. 1999. Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons. Am. J. Ind. Med. 36(1):54-59.
Doyle, P., E. Roman, V. Beral, and M. Brookes. 1997. Spontaneous abortion in dry cleaning workers potentially exposed to perchloroethylene. Occup. Environ. Med. 54(12):848-853.
Dreessen, B., G. Westphal, J. Bunger, E. Hallier, and M. Muller. 2003. Mutagenicity of the glutathione and cysteine S-conjugates of the haloalkenes 1,1,2-trichloro-3,3,3trifluoro-1-propene and trichlorofluoroethene in the Ames test in comparison with the tetrachloroethene-analogues. Mutat. Res. 539(1-2):157-166.
Echeverria, D., R.F. White, and C. Sampaio. 1995. A behavioral evaluation of PCE exposure in patients and dry cleaners: A possible relationship between clinical and preclinical effects. J. Occup. Environ. Med. 37(6):667-680.
Elfarra, A.A., and R.J. Krause. 2007. S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant. J. Pharmacol. Exp. Ther. 321(3): 1095-1101.
EPA (U.S. Environmental Protection Agency). 1991. Guidelines for Developmental Toxicity Risk Assessment. EPA/600/FR-91/001. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC. December 1991 [online]. Available: http://www.epa.gov/raf/publications/pdfs/DEVTOX.PDF [accessed Oct. 13, 2009].
EPA (U.S. Environmental Protection Agency). 1992. Guidance on Risk Characterization for Risk Managers and Risk Assessors. Memorandum to Assistant Administrators, and Regional Administrators, from F. Henry Habicht, Deputy Administrator, Office of the Administrator, Washington, DC. February 26, 1992 [online]. Available: http://www.epa.gov/oswer/riskassessment/pdf/habicht.pdf [accessed Oct. 13, 2009].
EPA (U.S. Environmental Protection Agency). 1995. Guidance for Risk Characterization. Science Policy Council, U.S. Environmental Protection Agency, Washington, DC. February 1995 [online]. Available: http://www.epa.gov/osa/spc/pdfs/rcguide.pdf [accessed Oct. 13, 2008].
EPA (U.S. Environmental Protection Agency). 1996. Guidelines for Reproductive Toxicity Risk Assessment. EPA/630/R-96/009. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC. October 1996 [online]. Available: http://www.epa.gov/ncea/raf/pdfs/repro51.pdf [accessed Oct. 13, 2009].
EPA (U.S. Environmental Protection Agency). 1997. Guiding Principles for Monte Carlo Analysis. EPA/630/R-97/001. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/NCEA/pdfs/montcarl.pdf [accessed Oct. 13, 2009].
EPA (U.S. Environmental Protection Agency). 1998. Guidance for Submission of Probabilistic Human Health Exposure Assessments to the Office of Pesticide Programs. Draft. Office of Pesticide Programs, U.S. Environmental Protection Agency. Nov. 4, 1998 [online]. Available: http://www.epa.gov/fedrgstr/EPA-PEST/1998/November/Day-05/6021.pdf [accessed Aug. 8, 2007].
EPA (U.S. Environmental Protection Agency). 2000. EPA Science Policy Council Handbook: Risk Characterization. EPA 100-B-00-002. Science Policy Council, U.S. Environmental Protection Agency, Washington, DC. December 2000 [online]. Available: http://www.epa.gov/osa/spc/pdfs/rchandbk.pdf [accessed Oct. 13, 2009].
EPA (U.S. Environmental Protection Agency). 2001. Risk Assessment Guidance for Superfund, Vol. III - Part A. Process for Conducting Probabilistic Risk Assessment. EPA 540-R-02-002. Office of Emergency and Remedial Response, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/oswer/riskassessment/rags3adt/ [accessed Aug. 8, 2009].
EPA (U.S. Environmental Protection Agency). 2002. A Review of the Reference Dose and Reference Concentration Processes. EPA/630/P-02/002F. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC [online]. Available: http://www.epa.gov/IRIS/RFD_FINAL%5B1%5D.pdf [accessed Oct. 22, 2009].
EPA (U.S. Environmental Protection Agency). 2005a. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC. March 2005 [online]. Available: http://earth1.epa.gov/ttn/atw/cancer_guidelines_final_3-25-05.pdf [accessed Oct. 13, 2009].
EPA (U.S. Environmental Protection Agency). 2005b. Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. EPA/630/R-03/003F. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC. March 2005 [online]. Available: http://earth1.epa.gov/ttn/atw/childrens_supplement_final.pdf [accessed Oct. 13, 2009].
EPA (U.S. Environmental Protection Agency). 2008. Toxicological Review of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in Support of Summary Information on the Integrated Risk Information System (IRIS). External Review Draft. U.S. Environmental Protection Agency, Washington, DC. June 2008 [online]. Available: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=192423 [accessed June 24, 2008].
EPA (U.S. Environmental Protection Agency). 2009. Using Probabilistic Methods to Enhance the Role of Risk Analysis in Decision-Making. External Review Draft. Prepared by Risk Assessment Forum PRA Technical Panel Working Groups, U.S. Environmental Protection Agency, Washington, DC.
EPA SAB (U.S. Environmental Protection Agency Science Advisory Board). 2007. Consultation on Enhancing Risk Assessment Practices and Updating EPA’s Exposure Guidelines. EPA-SAB-07-003. Letter from Rebecca T. Parkin, Chair, Integrated Human Exposure, Committee and Environmental Health Committee, and Granger Morgan, Chair, Science Advisory Board, to Stephen L. Johnson, Administrator, U.S. Environmental Protection Agency, Washington, DC. February 28, 2007 [online]. Available: http://yosemite.epa.gov/sab/sabproduct.nsf/02ad90b136fc21ef85256eba00436459/55E1B2C78C6085EB8525729C00573A3E/$File/sab-07-003.pdf [accessed Oct. 13, 2009].
Epstein, D.L., G.A. Nolen, J.L. Randall, S.A. Christ, E.J. Read, J.A. Stober, and M.K. Smith. 1992. Cardiopathic effects of dichloroacetate in the fetal Long-Evans rat. Teratology 46(3):225-235.
Ericksson, P., D. von Rosen, H. Viberg, and A. Frederiksson. 2005. Developmental toxicology in the neonatal mouse: The use of randomly selected individuals as statistical unit compared to the litter in mice neonatally exposed to PBDE 99. Toxicologist 84(S-1):219-220.
Eskenazi, B., L. Fenster, M. Hudes, A.J. Wyrobek, D.F. Katz, J. Gerson, and D.M. Rempel. 1991a. A study of the effect of perchloroethylene exposure on the reproductive outcomes of wives of dry-cleaning workers. Am. J. Ind. Med. 20(5):593-600.
Eskenazi, B., A.J. Wyrobek, L. Fenster, D.F. Katz, M. Sadler, J. Lee, M. Hudes, and D.M. Rempel. 1991b. A study of the effect of perchloroethylene exposure on semen quality in dry cleaning workers. Am. J. Ind. Med. 20(5):575-591.
Evans, J.S., J.D. Graham, G.M. Gray, and R.L. Sielken. 1994. A distributional approach to characterizing low-dose cancer risk. Risk Anal. 14(1):25-34.
Ferroni, C., L. Selis, A. Mutti, D. Folli, E. Bergamaschi, and I. Franchini. 1992. Neurobehavioral and neuroendocrine effects of occupational exposure to perchloroethylene. Neurotoxicology 13(1):243-247.
Frantz, S.W., and P.G. Watanabe. 1983. Tetrachloroethylene: Balance and tissue distribution in male Sprague-Dawley rats by drinking-water administration. Toxicol. Appl. Pharmacol. 69(1):66-72.
Fredriksson, M., B.R. Danielsson, and P. Eriksson. 1993. Altered behaviour in adult mice orally exposed to tri- and tetrachloroethylene as neonates. Toxicol. Lett. 66(1):13-19.
Galloway, S.M., M.J. Armstrong, C. Reuben, S. Colman, B. Brown, C. Cannon, A.D. Bloom, F. Nakamura, M. Ahmed, S. Duk, J. Rimpo, B.H. Margolin, M.A. Resnick, B. Anderson, and E. Zeiger. 1987. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Mol. Mutagen. 19(Suppl. 10):1-175.
Gearhart, J.M., D.A. Mahle, R.J. Greene, C.S. Seckel, C.D. Flemming, J.W. Fisher, and H.J. Clewell, III. 1993. Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE). Toxicol. Lett. 68(1-2):131-144.
Gennari, P., M. Naldi, R. Motta, M.C. Nucci, C. Giacomini, F.S. Violante, and G.B. Raffi. 1992. Gamma-glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene. Am. J. Ind. Med. 21(5):661-671.
Gobba, F. 2003. Occupational exposure to chemicals and sensory organs: A neglected research field. Neurotoxicology 24(4-5):675-691.
Gobba, F., E. Righi, G. Fantuzzi, G. Predieri, L. Cavazzuti, and G. Aggazzotti. 1998. Two-year evolution of perchloroethylene-induced color-vision loss. Arch. Environ. Health 53(3):196-198.
Goldsworthy, T.L., and J.A. Popp. 1987. Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity. Toxicol. Appl. Pharmacol. 88(2):225-233.
Goldsworthy, T.L., T. Smith-Oliver, D.J. Loury, J.A. Popp, and B.E. Butterworth. 1988. Assessment of chlorinated hydrocarbon-induced genotoxicity and cell replication in rat kidney cells. Environ. Mol. Mutagen. 11(Suppl. 11):39 [Abstract 92].
Grandjean, P., and P.J. Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet 368(9553):2167-2178.
Green, T., J. Odum, J.A. Nash, and J.R. Foster. 1990. Perchloroethylene-induced rat kidney tumors: An investigation of the mechanisms involved and their relevance to humans. Toxicol. Appl. Pharmacol. 103(1):77-89.
Guo, C., and K.E. McMartin. 2005. The cytotoxicity of oxalate, a metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation. Toxicology 208(3):347-355.
Hake, C.L., and R.D. Stewart. 1977. Human exposure to tetrachloroethylene: Inhalation and skin contact. Environ. Health Perspect. 21:231-238.
Hardin, B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles, and R.W. Niemeier. 1981. Testing of selected workplace chemicals for teratogenic potential. Scand. J. Work Environ. Health 7(Suppl. 4):66-75.
Hartmann, A., and G. Speit. 1995. Genotoxic effects of chemicals in the single cell gel (SCG) test with human blood cells in relation to the induction of sister-chromatid exchanges (SCE). Mutat. Res. 346(1):49-56.
Haseman, J.K., J.R. Hailey, and R.W. Morris. 1998. Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update. Toxicol. Pathol. 26(3):428-441.
Hill, B. 1965. The environment and disease: Association or causation? Proc. Royal Soc. Med. 58(May):295-300.
Honma, T., A. Sudo, M. Miyagawa, M. Sato, and H. Hasegawa. 1980. Effects of exposure to trichloroethylene and tetrachloroethylene on the contents of acetylcholine, dopamine, norepinephrine and serotonin in rat brain. Ind. Health 18(4):171-178.
Houston, J.B., and D.J. Carlile. 1997. Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. Drug. Metab. Rev. 29(4):891-922.
IARC (International Agency for Research on Cancer). 2004. Some Drinking-Water Disinfectants and Contaminants, Including Arsenic. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 84. Lyon: IARC.
IEc (Industrial Economics Inc.). 2006. Expanded Expert Judgment Assessment of the Concentration-Response Relationship Between PM2.5 Exposure and Mortality, Final Report. Prepared by Industrial Economics, Incorporated, Cambridge, MA, for Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, Research Triangle Park, NC. September 2006 [online]. Available: http://www.epa.gov/ttn/ecas/regdata/Uncertainty/pm_ee_report.pdf [accessed Oct. 14, 2009].
Ikeda, M., A. Koizumi, T. Watanabe, A. Endo, and K. Sato. 1980a. Cytogenetic and cytokinetic investigations on lymphocyes from workers occupationally exposed to tetrachloroethylene. Toxicol. Lett. 5(3-4):251-256.
Ikeda, M., A. Koizumi, T. Watanabe, A. Endo, and K. Sato. 1980b. Cytogenetic and cytokinetic investigations on lymphocytes from workers occupationally exposed to tetrachloroethylene. Dev. Toxicol. Environ. Sci. 8:347-350.
Ishmael, J., and P.H. Dugard. 2006. A review of perchloroethylene and rat mononuclear cell leukemia. Regul. Toxicol. Pharmacol. 45(2):178-184.
Ji, J., and K. Hemminki. 2005. Occurrences of leukemia subtypes by socioeconomic and occupational group. J. Occup. Environ. Med. 47(11):1131-1140.
Ji, J., and K. Hemminki. 2006. Socioeconomic/occupational risk factors for lymphoproliferative diseases in Sweden. Ann. Epidemiol. 16(5):370-376.
JISA (Japanese Industrial Safety Association). 1993. Carcinogenicity Study of Tetrachloroethylene by Inhalation in Rats and Mice. Data No. 3-1. Kanagawa, Japan: Japanese Industrial Safety Association.
Johnson, P.D., B.V. Dawson, and S.J. Goldberg. 1998. Cardiac teratogenicity of trichloroethylene metabolites. J. Am. Coll. Cardiol. 32(2):540-545.
Karlsson, J.E., L.E. Rosengren, P. Kjellstrand, and K.G. Haglid. 1987. Effects of lowdose inhalation of three chlorinated aliphatic organic solvents on deoxyribonucleic acid in gerbil brain. Scan. J. Work Environ. Health 13(5):453-458.`
Ketcha, M.M., D.K. Stevens, D.A. Warren, C.T. Bishop, and W.T. Brashear. 1996. Conversion of trichloroacetic acid to dichloroacetic acid in biological samples. J. Anal. Toxicol. 20(4):236-241.
King-Herbert, A., and K. Thayer. 2006. NTP Workshop: Animal models for the NTP rodent bioassay: Stocks and strains- should we switch? Toxicol. Pathol. 34(6):802805.
Kjellstrand, P., B. Holmquist, M. Kanje, P. Alm, S. Romare, I. Jonsson, L. Mansson, and M. Bjerkemo. 1984. Perchloroethylene: Effects on body and organ weights and plasma butyrylcholinesterase activity in mice. Acta Pharmacol. Toxicol. 54(5): 414-424.
Kjellstrand, P., B. Holmquist, I. Jonsson, S. Romare, and L. Mansson. 1985. Effects of organic solvents on motor activity in mice. Toxicology 35(1):35-46.
Klaassen, C.D., and G.L. Plaa. 1966. Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice. Toxicol. Appl. Pharmacol. 9(1):139-151.
Klaassen, C.D., and G.L. Plaa. 1967. Relative effects of various chlorinated hydrocarbons on liver and kidney function in dogs. Toxicol. Appl. Pharmacol. 10(1):119-131.
Krupnick, A., R. Morgenstern, M. Batz, P. Nelson, D. Burtraw, J. Shih, and M. McWilliams. 2006. Not a Sure Thing: Making Regulatory Choices Under Uncertainty. Washington, DC: Resources for the Future [online]. Available: http://www.rff.org/RFF/Documents/RFF-Rpt-RegulatoryChoices.pdf [accessed Oct. 14, 2009].
Kyrklund, T., and K. Haglid. 1991. Brain lipid composition in guinea pigs after intrauterine exposure to perchloroethylene. Pharmacol. Toxicol. 68(2):146-148.
Kyrklund, T., C. Alling, P. Kjellstrand, and K.G. Haglid. 1984. Chronic effects of perchloroethylene on the composition of lipid and acyl groups in cerebral cortex and hippocampus of the gerbil. Toxicol. Lett. 22(3):343-349.
Kyrklund, T., P. Kjellstrand, and K.G. Haglid. 1987. Lipid concentration and fatty acid pattern of the gerbil brain after exposure to perchloroethylene. Arch. Toxicol. 60(5):397-400.
Kyyronen, P., H. Taskinen, M.L. Lindbohm, K. Hemminki, and O.P. Heinonen. 1989. Spontaneous abortions and congenital malformations among women exposed to tetrachloroethylene in dry cleaning. J. Epidemiol. Community Health 43(4):346-351.
Larson, J.L., and R.J. Bull. 1992. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol. Appl. Pharmacol. 115(2):268-277.
Lash, L.H., and J.C. Parker. 2001. Hepatic and renal toxicities associated with perchloroethylene. Pharmacol. Rev. 53(2):177-208.
Lash, L.H., W. Qian, D.A. Putt, K. Desai, A.A. Elfarra, A.R. Sicuri, and J.C. Parker. 1998. Glutathione conjugation of perchloroethylene in rats and mice in vitro: Sex-, species-, and tissue-dependent differences. Toxicol. Appl. Pharmacol. 150(1):4957.
Lash, L.H., D.A. Putt, P. Huang, S.E. Hueni, and J.C. Parker. 2007. Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione. Toxicology 235(12):11-26.
Lauwerys, R., J. Herbrand, J.P. Buchet, A. Bernard, and J. Gaussin. 1983. Health surveillance of workers exposed to tetrachloroethylene in dry-cleaning shops. Int. Arch. Occup. Environ. Health 52(1):69-77.
Lezak, M.D., D.B. Howieson, D.W. Loring, H.J. Hannay, and J.S. Fischer, eds. 2004. Neuropsychological Assessment, 4th Ed. New York: Oxford University Press.
Lock, E.A., Y. Sani, R.B. Moore, M.B. Finkelstein, M.W. Anders, and A.A. Seawright. 1996. Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves. Arch. Toxicol. 70(10):607-619.
Lukaszewski, T. 1979. Acute tetrachloroethylene fatality. Clin. Toxicol. 15(4):411-415.
Lynge, E., and L. Thygesen. 1990. Primary liver cancer among women in laundry and dry-cleaning work in Denmark. Scand. J. Work Environ. Health 16(2):108-112.
Lynge, E., B. Carstensen, and O. Andersen. 1995. Primary liver cancer and renal cell carcinoma in laundry and dry-cleaning workers in Denmark. Scand. J. Work Environ. Health 21(4):293-295.
Lynge, E., A. Andersen, L. Rylander, H. Tinnerberg, M.L. Lindbohm, E. Pukkala, P. Romundstad, P. Jensen, L.B. Clausen, and K. Johansen. 2006. Cancer in persons working in dry cleaning in the Nordic countries. Environ. Health Perspect. 114(2):213-219.
Maltoni, C., and G. Cotti. 1986. Results of long-term carcinogenicity bioassays of tetrachloroethylene on Sprague-Dawley rats administered by ingestion. Acta Oncol. 7(1):11-26.
Mandel, J.S., J.K. McLaughlin, B. Schlehofer, A. Mellemgaard, U. Helmert, P. Lindblad, M. McCredie, and H.O. Adami. 1995. International renal-cell cancer study. IV. Occupation. Int. J. Cancer 61(5):601-605.
Marth, E. 1987. Metabolic changes following oral exposure to tetrachloroethylene in subtoxic concentrations. Arch. Toxicol. 60(4):293-299.
Marth, E., D. Stunzner, H. Binder, and J.R. Mose. 1985. Tetrachloroethylene: Effect of low concentrations of 1,1,2,2-tetrachloroethylene (tetrachloroethylenehloroethylene) on organisms in the mouse. II. Study of tetrachloroethylene in various organs and demonstration of histological changes in examined organs [in German]. Zentralbl. Bakteriol. Mikrobiol. Hyg. B. 181(6):541-547.
Marth, E., D. Stunzner, M. Kock, and J.R. Mose. 1989. Toxicokinetics of chlorinated hydrocarbons. J. Hyg. Epidemiol. Microbiol. Immunol. 33(4 suppl.):514-520.
Mattsson, J.L., R.R. Albee, B.L. Yano, G. Bradley, and P.J. Spencer. 1998. Neurotoxicologic examination of rats exposed to 1,1,2, 2-tetrachloroethylene (perchloroethylene) vapor for 13 weeks. Neurotoxicol. Teratol. 20(1):83-98.
Mazullo, M, S. Grilli, G. Lattanzi, G. Prodi, M.P. Turina, and A. Colacci. 1987. Evidence of DNA binding activity of perchloroethylene. Res. Commun. Chem. Pathol. Pharmacol. 58(2):215-235.
McGoldrick, T.A., E.A. Lock, V. Rodilla, and G.M. Hawksworth. 2003. Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells. Arch. Toxicol. 77(7):365-370.
Meek, M.E. 2008. Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals. Environ. Mol. Mutagen. 49(2):110-116.
Mellemgaard, A., G. Engholm, J.K. McLaughlin, and J.H. Olsen. 1994. Occupational risk factors for renal-cell carcinoma in Denmark. Scand. J. Work Environ. Health 20(3):160-165.
Mihic, S.J. 1999. Acute effects of ethanol on GABAA and glycine receptor function. Neurochem. Int. 35(2):115-123.
Miligi, L., A.S. Costantini, A. Benvenuti, D. Kriebel, V. Bolejack, R. Tumino, V. Ramazzotti, S. Rodella, E. Stagnaro, P. Crosignani, D. Amadori, D. Mirabelli, L. Sommani, I. Belletti, L. Troschel, L. Romeo, G. Miceli, G.A. Tozzie, I. Mendico, and P. Vineis. 2006. Occupational exposure to solvents and the risk of lymphomas. Epidemiology 17(5):552-561.
Miller, R.E., and F.P. Guengerich. 1982. Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide. Biochemistry 21(5):1090-1097.
Milman, H.A., D.L. Story, E.S. Riccio, A. Sivak, A.S. Tu, G.M. Williams, C. Tong, and C.A. Tyson. 1988. Rat liver foci and in vitro assays to detect initiating and promoting effects of chlorinated ethanes and ethylenes. Ann. N.Y. Acad. Sci. 534:521530.
Monster, A.C., G. Boersma, and H. Steenweg. 1979. Kinetics of tetrachloroethylene in volunteers: influence of exposure concentration and work load. Int. Arch. Occup. Environ. Med. 42(3-4):303-309.
Moore, M.M., and K. Harrington-Brock. 2000. Mutagenicity of trichloroethylene and its metabolites: Implications for the risk assessment of trichloroethylene. Environ. Health Perspect. 108(Suppl. 2):215-223.
Morgan, M.G., and M. Henrion. 1990. Uncertainty: A Guide to Dealing with Uncertainty in Quantitative Risk and Policy Analysis. New York: Cambridge University Press.
Morton, W., and D. Marjanovic. 1984. Leukemia incidence by occupation in the Portland-Vancouver metropolitan area. Am. J. Ind. Med. 6(3):185-205.
Moser, V.C., B.M. Cheek, and R.C. MacPhail. 1995. A multidisciplinary approach to toxicological screening: III. Neurobehavioral toxicity. J. Toxicol. Environ. Health 45(2):173-210.
Motohashi, Y., Y. Miyazaki, and T. Takano. 1993. Assessment of behavioral effects of tetrachloroethylene using a set of time-series analyses. Neurtoxicol. Teratol. 15(1):3-10.
Muller, M., G. Birner, and W. Dekant. 1998a. Reactivity of haloketenes and halothioketenes with nucleobases: Chemical characterization of reaction products. Chem. Res. Toxicol. 11(5):454-463.
Muller, M., G. Birner, M. Sander, and W. Dekant. 1998b. Reactivity of haloketenes and halothioketenes with nucleobases: Reactions in vitro with DNA. Chem. Res. Toxicol. 11(5):464-470.
Murakami, K., and K. Horikawa. 1995. The induction of micronuclei in mice hepatocytes and reticulocytes by tetrachloroethylene. Chemosphere 31(7):3733-3739.
Nagano, K., T. Nishizawa, S. Yamamoto, and T. Matsushima. 1998. Inhalation carcinogenesis studies of six halogenated hydrocarbons in rats and mice. Pp. 741-746 in Advances in the Prevention of Occupational Respiratory Diseases: Proceedings of the 9th International Conference on Occupational Respiratory Disease, Kyoto, Japan, 13-16 October 1997, K. Chiyotani, Y. Hosoda, and Y. Aizawa, eds. Amsterdam: Elsevier.
Nakajima, T., Y. Kamijo, N. Usuda, Y. Liang, Y. Fukushima, K. Kametani, F.J. Gonzalez, and T. Aoyama. 2000. Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPARalpha). Carcinogenesis 21(4):677-682.
NCI (National Cancer Institute). 1977. Bioassay of Tetrachloroethylene for Possible Carcinogenicity. NCI-CG-TR-13. DHEW(NIH)77-813. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institute of Health, Bethesda, MD [online]. Available: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr013.pdf [accessed Oct. 14, 2009].
Nelson, B.K., B.J. Taylor, J.V. Setzer, and J.W. Hornung. 1979. Behavioral teratology of perchloroethylene in rats. J. Environ. Pathol. Toxicol. 3(1-2):233-250.
NRC (National Research Council). 1983. Risk Assessment in the Federal Government: Managing the Process. Washington, DC: National Academy Press.
NRC (National Research Council). 1989. Improving Risk Communication. Washington, DC: National Academy Press.
NRC (National Research Council). 1993. Issues in Risk Assessment. Washington, DC: National Academy Press.
NRC (National Research Council). 1994. Science and Judgment in Risk Assessment. Washington, DC: National Academy Press.
NRC (National Research Council). 2002. Estimating the Public Health Benefits of Proposed Air Pollution Regulations. Washington, DC: The National Academies Press.
NRC (National Research Council). 2006a. Assessing the Human Health Risks of Trichloroethylene. Washington, DC: The National Academies Press.
NRC (National Research Council). 2006b. Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment. Washington, DC: The National Academies Press.
NRC (National Research Council). 2007. Models in Environmental Regulatory Decision Making. Washington, DC: The National Academies Press.
NRC (National Research Council). 2009. Science and Decisions: Advancing Risk Assessment. Washington, DC: The National Academies Press.
NTP (National Toxicology Program). 1986. Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) CAS No. 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP TR 311. NIH Publication No. 86-2567. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC.
Odum, J., T., Green, J.R. Foster, and P.M. Hext. 1988. The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Toxicol. Appl. Pharmacol. 92(1):103-112.
Olsen, J., K. Hemminki, G. Ahlborg, T. Bjerkedal, P. Kyyronen, H. Taskinen, M.L. Lindbohm, O.P. Heinonen, L. Brandt, H. Kolstad, B.A. Halvorsen, and J. Egenaes. 1990. Low birth weight, congenital malformations, and spontaneous abortions among dry-cleaning workers in Scandinavia. Scand. J. Work Environ. Health 16(3):163-168.
Oshiro, W.M., Q.T. Krantz, and P.J. Bushnell. 2008. Characterization of the effects of inhaled perchloroethylene on sustained attention in rats performing a visual signal detection task. Neurotoxicol. Teratol. 30(3):167-174.
Ozkaynak, H., H.C. Frey, J. Burke, and R.W. Pinder. 2008. Analysis of coupled model uncertainties in source to dose modeling of human exposures to ambient air pollution: A PM2.5 case-study. Atmos. Environ. 43(9):1641-1649.
Pahler, A., G. Birner, J. Parker, and W. Dekant. 1998. Generation of antibodies to di- and trichloroacetylated proteins and immunochemical detection of protein adducts in rats treated with perchloroethene. Chem. Res. Toxicol. 11(9):995-1004.
Pahler, A., J. Parker, and W. Dekant. 1999. Dose-dependent protein adduct formation in kidney, liver, and blood of rats and in human blood after perchloroethene inhalation. Toxicol. Sci. 48(1):5-13.
Pang, K.S. 2009. Safety testing of metabolites: Expectations and outcomes. Chem. Biol. Interact. 179(1):45-49.
Parrish, J.M., E.W. Austin, D.K. Stevens, D.H. Kinder, and R.J. Bull. 1996. Haloacetateinduced oxidative damage to DNA in the liver of male B6C3F1 mice. Toxicology 100(1-3):103-111.
Partanen, T., P. Heikkila, S. Hernberg, T. Kauppinen, G. Moneta, and A. Ojajarvi. 1991. Renal cell cancer and occupational exposure to chemical agents. Scand. J. Work Environ. Health 17(4):231-239.
PCCRARM (Presidential/Congressional Commission on Risk Assessment and Risk Management). 1997. Framework for Environmental Health Risk Management Final Report, Volume 1 [online]. Available: http://www.riskworld.com/nreports/1997/riskrpt/pdf/EPAJAN.PDF [accessed Oct. 14, 2009].
Pegg, D.G., J.A. Zempel, W.H. Braun, and P.G. Watanabe. 1979. Disposition of tetrachloro(14C)ethylene following oral and inhalation exposure in rats. Toxicol. Appl. Pharmacol. 51(3):456-474.
Perocco, P., S. Bolognesi, and W. Alberghini. 1983. Toxic activity of seventeen industrial solvents and halogentated compounds on human lymphocytes cultured in vitro. Toxicol. Lett. 16(1-2):69-75.
Pesch, B., J. Haerting, U. Ranft, A. Klimpel, B. Oelschlagel, W. Schill, and MURC Study Group. 2000. Occupational risk factors for renal cell carcinoma: Agent-specific results from a case-control study in Germany. Int. J. Epidemiol. 29(6):1014-1024.
Philip, B.K., M.M. Mumtaz, J.R. Latendresse, and H.M. Mehendale. 2007. Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice. Toxicology 232(1-2):1-14.
Potter, C.L., L.W. Chang, A.B. DeAngelo, and F.B. Daniel. 1996. Effects of four trihalomethanes on DNA strand breaks, renal hyaline droplet formation and serum testosterone in male F-344 rats. Cancer Lett. 106(2):235-242.
Rao, V.R., and D.R. Brown. 1993. A physiologically based pharmacokinetic assessment of tetrachloroethylene in groundwater for a bathing and showering determination. Risk Anal. 13(1):37-49.
Reitz, R.H., M.L. Gargas, A.L. Mendrala, and A.M. Schumann. 1996. In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans. Toxicol. Appl. Pharmacol. 136(2):289306.
Ripp, S.L., L.H. Overby, R.M. Philpot, and A.A. Elfarra. 1997. Oxidation of cysteine S-conjugates by rabbit liver microsomes and cDNA-expressed flavin-containing monooxygenases: Studies with S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2,2-trichlorovinyl)-L-cysteine, S-allyl-L-cysteine, and S-benzyl-L-cysteine. Mol. Pharmacol. 51(3):507-515.
Rosengren, L.E., P. Kjellstrand, and K.G. Haglid. 1986. Tetrachloroethylene: Levels of DNA and S-100 in the gerbil CNS after chronic exposure. Neurobehav. Toxicol. Teratol. 8(2):201-206.
Ruder, A.M., E.M. Ward, and D.P. Brown. 2001. Mortality in dry-cleaning workers: An update. Am. J. Ind. Med. 39(2):121-132.
Savolainen, H., P. Pfaffli, M. Tengen, and H. Vainio. 1977. Biochemical and behavioral effects of inhalation exposure to tetrachloroethylene and dichloromethane. J. Neuropathol. Exp. Neurol. 36(6):941-949.
Schlehofer, B., C. Heuer, M. Blettner, D. Niehoff, and J. Wahrendorf. 1995. Occupation, smoking and demographic factors, and renal cell carcinoma in Germany. Int. J. Epidemiol. 24(1):51-57.
Schreiber, J.S., H.K. Hudnell, A.M. Geller, D.E. House, K.M. Aldous, M.S. Force, K. Langguth, E.J. Prohonic, and J.C. Parker. 2002. Apartment residents’ and day care workers’ exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Environ. Health Perspect. 110(7):655-664.
Schumann, A.M., J.F. Quast, and P.G. Watanabe. 1980. The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity. Toxicol. Appl. Pharmacol. 55(2):207-219.
Schwetz, B.A., K.J. Leong, and P.J. Gehring. 1975. The effect of maternally inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats. Toxicol. Appl. Pharmacol. 32(1):84-96.
Scott, W.J., Jr, M.D. Collins, and H. Nau. 1994. Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids. Environ. Health Perspect. 102 (Suppl. 11):97-101.
Seeber, A. 1989. Neurobehavioral toxicity of long-term exposure to tetrachloroethylene. Neurotoxicol. Teratol. 11(6):570-583.
Seidel, H.J., L. Weber, and E. Barthel. 1992. Hematological toxicity of tetrachloroethylene in mice. Arch. Toxicol. 66(3):228-230.
Shafer, T.J., P.J. Bushnell, V.A. Benignus, and J.J. Woodward. 2005. Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents. J. Pharmacol. Exp. Ther. 315(3):1109-1118.
Shimada, T. A.F. Swanson, P. Leber, and G.M. Williams. 1985. Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/DNA repair assays under vapor phase exposure conditions. Cell Biol. Toxicol. 1(3):159-179.
Slikker, W., Jr. 1994. Principles of developmental neurotoxicology. Neurotoxicology 15 (1):11-16.
Small, M.J. 2008. Methods for assessing uncertainty in fundamental assumptions and associated models for cancer risk assessment. Risk Anal. 28(5):1289-1307.
Smith, M.K., J.L. Randall, E.J. Read, and J.A. Stober. 1989. Teratogenic activity of trichloroacetic acid in the rat. Teratology 40(5):445-451.
Smith, M.K., J.L. Randall, E.J. Read, and J.A. Stober. 1992. Developmental toxicity of dichloroacetate in the rat. Teratology 46(3):217-223.
Sofuni, T., M. Hayashi, A. Matsuoka, M. Sawada, M. Hatanaka, and M. Ishidate, Jr.. 1985. Mutagenicity tests on organic chemical contaminants in city water and related compounds. II. Chromosome aberration tests in cultured mammanlian cells [in Japanese]. Eisei Shikenjo Hokoku 103:64-75.
Sonnenfeld, N., I. Hertz-Picciotto, and W.E. Kaye. 2001. Tetrachloroethylene in drinking water and birth outcomes at the U.S. Marine Corps Base at Camp Lejeune, North Carolina. Am. J. Epidemiol. 154(10):902-908.
Spinatonda, G., R. Colombo, E.M. Capodaglio, M. Imbriani, C. Pasetti, G. Minuco, and P. Pinelli. 1997. Process of speech production: Application in a group of subjects chronically exposed to organic solvents (II) [in Italian]. G. Ital. Med. Lav. Ergon. 19(3):85-88.
Spirtas, R., P.A. Stewart, J.S. Lee, D.E. Marano, C.D. Forbes, D.J. Grauman, H.M. Pettigrew, A. Blair, R.N. Hoover, and J.L. Cohen. 1991. Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results. Br. J. Ind. Med. 48(8):515-530.
Stewart, R.D., and H.C. Dodd. 1964. Absorption of carbon tetrachloride, trichloroethylene, tetrachloroethylene, methylene chloride, and 1,1,1-trichloroethane through the human skin. Am. Ind. Hyg. Assoc. J. 25:439-446.
Storer, R.D., T.W. McKelvey, A.R. Kraynak, M.C. Elia, J.E. Barnum, L.S. Harmon, W.W. Nichols, and J.G. DeLuca. 1996. Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: Improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds. Mutat. Res. 368(2):59-101.
Storm, J.E., and K.A. Mazor. 2004. Update of residential tetrachloroethylene exposure and decreases in visual contrast sensitivity. Environ. Health Perspect. 112(15):A8 62-A864.
Stromberg, P.C. 1985. Large granular lymphocyte leukemia in F344 rats: A model for human T gamma lymphoma, malignant histiocytosis, and T-cell chronic lymphocytic leukemia. Am. J. Pathol. 119(3):517-519.
Sweeney, L.M., C.R. Kirman, M.L. Gargas, and P.H. Dugard. 2009. Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice. Toxicology 260(1-3):77-83.
Szakmary, E., G. Ungvary, and E. Tatrai. 1997. The offspring-damaging effect of tetrachloroethylene in rats, mice, and rabbits. Cent. Eur. J. Occup. Environ. Med. 3(1): 31-39.
Thomas, J., J.K. Haseman, J.I. Goodman, J.M. Ward, T.P. Loughran, Jr., and P.J. Spencer. 2007. A review of large granular lymphocytic leukemia in Fischer 344 rats as an initial step toward evaluating the implication of the endpoint to human cancer risk assessment. Toxicol. Sci. 99(1): 3-19.
Tinston, D.J. 1994. Perchloroethylene: A Multigeneration Inhalation Study in the Rat. Report No. CTL/P/4097. Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK. November 3, 1994.
Toraason, M., J. Clark, D. Dankovic, P. Mathias, S. Skaggs, C. Walker, and D. Werren. 1999. Oxidative stress and DNA damage in Fischer rats following acute exposure to trichloroethylene or perchloroethylene. Toxicology 138(1):43-53.
Toraason, M., M.A. Butler, A. Ruder, C. Forrester, L. Taylor, D.L. Ashley, P. Mathias, K.L. Marlow, K.L. Cheever, E. Krieg, and H. Wey. 2003. Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners. Mutat. Res. 539(1-2):9-18.
Travier, N., G. Gridley, A.J. De Roos, N. Plato, T. Moradi, and P. Boffetta. 2002. Cancer incidence of dry cleaning, laundry, and ironing workers in Sweden. Scand. J. Work Environ. Health 28(5):341-348.
Tu, A.S., T.A. Murray, K.M. Hatch, A. Sivak, and H.A. Milman. 1985. In vitro transformation of BALB/c-3T3 cells by chlorinated ethanes and ethylenes. Cancer Lett. 28(1):85-92.
Umezu, T., J. Yonemoto, Y. Soma, and T. Miura. 1997. Behavioral effects of trichloroethylene and tetrachloroethylene in mice. Pharmacol. Biochem. Behav. 58(3):665-671.
Vamvakas, S., W. Dekant, and D. Henschler. 1989a. Genotoxocity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells. Toxicol. In Vitro 3(2): 151-156.
Vamvakas, S., A. Kochling, H. Berthold, and W. Dekant. 1989b. Cytotoxicity of cysteine S-conjugates: Structure-activity relationships. Chem. Biol. Interact. 71(1):79-90.
Vamvakas, S., W. Dekant, and D. Henschler. 1989c. Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine Sconjugates of haloalkenes and haloalkanes. Mutat. Res. 222(4):329-335.
Vamvakas, S., M. Herkenhoff, W. Dekant, and D. Henschler. 1989d. Mutagenicity of tetrachloroethylene in the Ames test—metabolic activation by conjugation with glutathione. J. Biochem. Toxicol. 4(1):21-27.
Vaughan, T.L., P.A. Stewart, S. Davis, and D.B. Thomas. 1997. Work in dry-cleaning and the incidence of cancer of the oral cavity, larynx, and esophagus. Occup. Environ. Med. 54(9):692-695.
Verplanke, A.J., M.H. Leummens, and R.F. Herber. 1999. Occupational exposure to tetrachloroethylene and its effects on the kidneys. J. Occup. Environ. Med. 41(1):11-16.
Volkel, W., and W. Dekant. 1998. Chlorothioketene, the ultimate reactive intermediate formed by cysteine conjugate beta-lyase-mediated cleavage of the trichloroethene metabolite S-(1,2-dichlorovinyl)-L-cysteine, forms cytosine adducts in organic solvents, but not in aqueous solution. Chem. Res. Toxicol. 11(9):1082-1088.
Volkel, W., M. Friedewald, E. Lederer, A. Pahler, J. Parker, and W. Dekant. 1998. Biotransformation of perchloroethene: Dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-cysteine in rats and humans after inhalation. Toxicol. Appl. Pharmacol. 153(1):20-27.
Von Tungeln, L.S., P. Yi, T.J. Bucci, V.M. Samokyszyn, M.W. Chou, F.F. Kadlubr, and P.P. Fu. 2002. Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse. Cancer Lett. 185(1):13-19.
Vose, D. 2008. Risk Analysis: A Quantitative Guide, 3rd Ed. Chichester, England: John Wiley and Sons.
Vyskocil, A., S. Emminger, J. Tejral, Z. Fiala, E. Ettlerova, and A. Cermanova. 1990. Study on kidney function in female workers exposed to perchloroethylene. Hum. Exp. Toxicol. 9(6):377-380.
Walles, S.A. 1986. Inducation of single-strand breaks in DNA of mice by trichloroethylene and tetrachloroethylene. Toxicol. Lett. 31(1):31-35.
Wang, J.L., W.L. Chen, S.Y. Tsai, P.Y. Sung, and R.N. Huang. 2001. An in vitro model for evaluation of vaporous toxicity of trichloroethylene and tetrachloroethylene to CHO-K1 cells. Chem. Biol. Interact. 137(2):139-154.
Wang, S., J.E. Karlsson, T. Kyrklund, and K. Haglid. 1993. Perchloroethylene-induced reduction in glial and neuronal cell marker proteins in rat brain. Pharmacol. Toxicol. 72(4-5):273-278.
Warren, D.A., T.G. Reigle, S. Muralidhara, and C.E. Dallas. 1996. Schedule-controlled operant behavior of rats following oral administration of perchloroethylene: Time course and relationship to blood and brain solvent levels. J. Toxicol. Environ. Health 47(4):345-362.
Werner, M., G. Birner, and W. Dekant. 1996. Sulfoxidation of mercapturic acids derived from tri- and tetrachloroethene by cytochromes P450 3A: A bioactivation reaction in addition to deacetylation and cysteine conjugate beta-lyase mediated cleavage. Chem. Res. Toxicol. 9(1):41-49.
White, I.N., N. Razvi, A.H. Gibbs, A.M. Davies, M. Manno, C. Zaccaro, F. De Matteis, A. Pahler, and W. Dekant. 2001. Neoantigen formation and clastogenic action of
HCFC-123 and perchloroethylene in human MCL-5 cells. Toxicol. Lett. 124(1-3):129-138.
WHO (World Health Organisation). 2008. Harmonization Project Document No. 6, Part 1: Guidance Document on Characterizing and Communicating Uncertainty in Exposure Assessment, International Program on Chemical Safety, World Health Organization, and Co-sponsored by International Labour Organization, and the United Nations Environmental Programme. Geneva, Switzerland: WHO [online]. Available: http://www.who.int/ipcs/publications/methods/harmonization/exposure_assessment.pdf [accessed Oct. 14, 2009].
Windham, G.C., D. Shusterman, S.H. Swan, L. Fenster, and B. Eskenazi. 1991. Exposure to organic solvents and adverse pregnancy outcome. Am. J. Ind. Med. 20(2):241-259.
Yoshioka, T., J.A. Krauser, and F.P. Guengerich. 2002. Tetrachloroethylene oxide: Hydrolytic products and reactions with phosphate and lysine. Chem. Res. Toxicol. 15(8):1096-1105.
