BOX ES-1

Summary of the Committee’s Goals and Recommendations

Goal I. Improve the speed and efficiency of the design, launch, and conduct of clinical trials

  1. Review and consolidate some front office operationsa of the Cooperative Groups on the basis of peer review

  2. Consolidate back office operations of the Cooperative Groups and improve processesb

  3. Streamline and harmonize government oversight

  4. Improve collaboration among stakeholders

Goal II. Incorporate innovative science and trial design into cancer clinical trials

  1. Support and use biorepositories

  2. Develop and evaluate novel trial designs

  3. Develop standards for new technologies

Goal III. Improve the means of prioritization, selection, support, and completion of cancer clinical trials

  1. Reevaluate the role of NCI in the clinical trials system

  2. Increase the accrual volume, diversity, and speed of clinical trials

  3. Increase funding for the Cooperative Group Program

Goal IV. Incentivize the participation of patients and physicians in clinical trials

  1. Support clinical investigators

  2. Cover the cost of patient care in clinical trials

  

aFront office operations refer primarily to the Cooperative Group scientific committees and statistical offices, which are responsible for activities such as trial design, prioritization, and data analysis.

  

bBack office operations refer to administrative structures and activities that include such things as data collection and management, data queries and reviews, patient registration, audit functions, case report form processing, image storage and retrieval, drug distribution, credentialing of sites, and funding and reimbursement for patient accrual.



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