FIGURE 4-1 Classification system for the spectrum of acute coronary syndromes that helps practitioners identify a study population more easily.

FIGURE 4-1 Classification system for the spectrum of acute coronary syndromes that helps practitioners identify a study population more easily.

NOTE: MI = myocardial infarction.

SOURCE: Califf, 2009. (Adapted from 2007 American Heart Association/American College of Cardiology Guidelines.) Reprinted with permission from Robert Califf 2010.

BOX 4-1

Case Study: Acute Decompensated Heart Failure and Acute Myocardial Infarction

The importance of developing a practical inception point for a disease is highlighted by comparing two diseases—acute decompensated heart failure and acute myocardial infarction (MI). The two diseases affect the same number of people and have roughly the same mortality and readmission risks. As illustrated in the table below, in 2006 acute decompensated heart failure lacked evidence-based guidelines, whereas acute MI had a robust base of scientific evidence based on large randomized trials.



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