Temperature is best regulated by having thermostatic control for each holding space. Use of zonal control for multiple spaces can result in temperature variations between spaces in the zone because of differences in animal densities and heat gain or loss in ventilation ducts and other surfaces within the zone. Individual space control is generally accomplished by providing each space with a dedicated reheat coil. Valves controlling reheat coils should fail in the closed position; steam coils should be avoided or equipped with a high-temperature cut-off system to prevent space overheating and animal loss with valve failure.

Humidification is typically controlled and supplemented on a system or zone basis. Control of humidification in individual holding spaces may be desirable for selected species with reduced tolerance for low relative (e.g., nonhuman primates) or high humidity (e.g., rabbits).

Most HVAC systems are designed for average high and low temperatures and humidities experienced in a geographic area within ±5% variation (ASHRAE 2009). Moderate fluctuations in temperature and relative humidity outside suggested ranges are generally well tolerated by most species commonly used in research as long as they are brief and infrequent; holding spaces should be designed to minimize drafts and temperature gradients. Consideration should be given to measures that minimize fluctuations in temperature and relative humidity outside the recommended ranges due to extremes in the external ambient environment. Such measures can include partial redundancy, partial air recirculation, altered ventilation rates, or the use of auxiliary equipment. In the event of an HVAC system or component failure, systems should at the minimum supply facility needs at a reduced level, address the adverse effects of loss of temperature control, and, where necessary, maintain critical pressurization gradients. It is essential that life-threatening heat accumulation or loss be prevented during mechanical failure. Temporary needs for ventilation of sheltered or outdoor facilities can usually be met with auxiliary equipment.

Air handling system intake locations should avoid entrainment of fumes from vehicles, equipment, and system exhaust. While 100% outside air is typically provided, when recirculated air is used its quality and quantity should be in accord with recommendations in Chapter 3. The type and efficiency of supply and exhaust air treatment should be matched to the quantity and types of contaminants and to the risks they pose. Supply air is usually filtered with 85–95% dust spot efficient filters (ASHRAE 2008). In certain instances, higher efficiency filters (e.g., HEPA) may be beneficial for recirculated supply air and air supplied to or exhausted from specialized areas such as surgical and containment facilities (Kowalski et al. 2002).



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