scope and nature of this responsibility can vary based on the scientific discipline, nature of the animal use, and species involved, but because it affects animal care and use in every situation this responsibility requires that producers, teachers, researchers, and institutions carry out purposeful analyses of proposed uses of laboratory animals. The Guide is central to these analyses and to the development of a program in which humane care is incorporated into all aspects of laboratory animal care and use.

APPLICABILITY AND GOALS

In the Guide, laboratory animals (also referred to as animals) are generally defined as any vertebrate animal (i.e., traditional laboratory animals, agricultural animals, wildlife, and aquatic species) produced for or used in research, testing, or teaching. Animal use is defined as the proper care, use, and humane treatment of laboratory animals produced for or used in research, testing, or teaching.

Laboratory animals or animals: Any vertebrate animal (e.g., traditional laboratory animals, agricultural animals, wildlife, and aquatic species) produced for or used in research, testing, or teaching.

When appropriate, considerations or specific emphases for agricultural animals and nontraditional species are presented. The Guide does not address in detail agricultural animals used in production, agricultural research or teaching, wildlife and aquatic species studied in natural settings, or invertebrate animals (e.g., cephalopods) used in research, but establishes general principles and ethical considerations that are also applicable to these species and situations. References provide the reader with additional resources, and supplemental information on breeding, care, management, and use of selected laboratory animal species is available in other publications prepared by the Institute for Laboratory Animal Research (ILAR) and other organizations (Appendix A).

Animal use: The proper care, use, and humane treatment of laboratory animals produced for or used in research, testing, or teaching.

The goal of the Guide is to promote the humane care and use of laboratory animals by providing information that will enhance animal wellbeing, the quality of research, and the advancement of scientific knowledge that is relevant to both humans and animals. The Committee recognizes that the use of different species in research is expanding and that researchers and institutions will face new and unique challenges in determining how to apply the Guide in these situations. In making such determinations, it is



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