Appendix C
Symposium Agenda
TOXICITY-PATHWAY-BASED RISK ASSESSMENT: PREPARING FOR PARADIGM CHANGE
Public Meeting: May 11-13, 2009
National Academy of Sciences
2101 Constitution Avenue, NW
Washington, DC 20418
MONDAY, MAY 11, 2009
A PARADIGM CHANGE ON THE HORIZON
8:30 |
Welcome and Introduction |
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Warren Muir Executive Director, Division on Earth and Life Studies National Academies |
8:35 |
Background on Standing Committee on Risk Analysis Issues and Reviews |
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Bernard Goldstein Chair, Standing Committee on Risk Analysis Issues and Reviews Professor, Department of Environmental and Occupational Health University of Pittsburgh |
8:40 |
EPA Expectations on Symposium |
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Peter Preuss Director, National Center for Environmental Assessment U.S. Environmental Protection Agency |
8:45 |
Making Risk Assessment More Useful to Public and Private Decision-Makers in an Era of Paradigm Change |
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E. Donald Elliott Member, Board on Environmental Studies and Toxicology National Academies Former EPA General Counsel |
9:15 |
Emerging Science and Public Health |
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Lynn Goldman Member, Symposium Planning Committee Member, Standing Committee on Risk Analysis Issues and Reviews Professor and Chair, Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health |
9:45 |
Toxicity Testing in the 21st Century |
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Kim Boekelheide Professor of Medical Sciences Brown University |
10:15 |
Symposium Roadmap |
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Lorenz Rhomberg Chair, Symposium Planning Committee Member, Standing Committee on Risk Analysis Issues and Reviews Principal, Gradient Corporation |
10:45 |
Break |
THE NEW SCIENCE
Moderator: Lorenz Rhomberg, Chair, Symposium Planning Committee; Member, Standing Committee on Risk Analysis Issues and Reviews; Principal, Gradient Corporation |
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11:00 |
Overview of New Science |
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John Groopman Anna M. Baetjer Professor of Environmental Health and Chair Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health |
11:30 |
Gene-Environment Interactions |
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George Leikauf Member, Symposium Planning Committee Professor, University of Pittsburgh |
12:00 |
Tools and Technologies for Pathway-Based Research |
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Ivan Rusyn Associate Professor, Department of Environmental Science and Engineering University of North Carolina at Chapel Hill |
12:30 |
Lunch |
PATHWAY-BASED APPROACHES FOR HAZARD ID
Moderator: Michael Lawton, Member, Symposium Planning Committee; Associate Research Fellow, Head, Molecular Toxicology Group, Pfizer, Inc. |
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1:30 |
ToxCast: Redefining Hazard Identification |
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Robert Kavlock Director, National Center for Computational Toxicology U.S. Environmental Protection Agency |
2:00 |
Practical Applications: Pharmaceuticals |
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William Pennie Executive Director, Compound Safety Prediction Worldwide Medicinal Chemistry Pfizer Global Research and Development |
2:30 |
Practical Applications: Consumer Products |
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George Daston Research Fellow Procter & Gamble Company |
3:00 |
Break |
3:15 |
Practical Applications: Mixtures |
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John Groten Vice President, Drug Safety Europe Schering-Plough |
3:45 |
Pathway-Based Approaches: A European/REACH Perspective |
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Thomas Hartung Director, Center for Alternatives to Animal Testing Johns Hopkins University |
4:15 |
Panel Discussion |
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Panelists: Speakers and invited panelists (Charles Auer, former Director, Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency (retired); David Jacobson-Kram, Associate Director for Pharmacology and Toxicology, U.S. Food and Drug Administration) |
5:00 |
Break |
5:30 |
Poster Session |
7:00 |
Adjourn |
TUESDAY, MAY 12, 2009
APPLICATION TO MODE-OF-ACTION ANALYSIS
Moderator: Lauren Zeise, Member, Symposium Planning Committee; Chief, Reproductive and Cancer Hazard Assessment Section, California Environmental Protection Agency |
|
8:30 |
What is Required for Acceptance |
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John Bucher Associate Director, National Toxicology Program National Institute of Environmental Health Sciences |
9:00 |
Environmental Disease: Evaluation at the Molecular Level |
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Kenneth Ramos Distinguished Professor, Department of Biochemistry and Molecular Biology University of Louisville Health Science Center |
9:30 |
Dioxin: Evaluation of Pathways at the Molecular Level |
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Alvaro Puga Professor University of Cincinnati |
10:00 |
Systems Level Approaches for Understanding Principals of Nanomaterial Biocompatibility |
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Brian Thrall Technical Group Leader, Cell Biology Group Pacific Northwest National Laboratory |
10:30 |
Break |
11:00 |
Panel Discussion |
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Panelists: Speakers and invited panelists (William Kaufmann, Professor of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill; Jonathan Wiener, Perkins Professor of Law and Professor of Environmental Policy & Public Policy Studies, Duke University; Past President, Society for Risk Analysis) |
12:00 |
Lunch |
CHALLENGES AND OPPORTUNITIES FOR RISK ASSESSMENT IN THE CHANGING PARADIGM
Moderator: Joel Pounds, Member, Symposium Planning Committee; Senior Staff Scientist, Advisor to the Environmental Biomarkers Initiative, Pacific Northwest National Laboratory |
|
1:00 |
Dose and Temporal Response |
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Elaine Faustman Member, Symposium Planning Committee Professor, Environmental and Occupational Health University of Washington |
1:30 |
Application of Genomic Dose-Response Data to Define Mode-of-Action and Low-Dose Behavior of Chemical Toxicants |
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Rusty Thomas Director, Functional Genomics The Hamner Institutes for Health Sciences |
2:00 |
Using PBPK Models to Interpret Dose-Response of –Omics Data |
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Gregory L. Kedderis Independent Researcher and Consultant Chapel Hill, North Carolina |
2:30 |
Modular Network Modeling of Toxicity Pathways for Extrapolation |
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Katrina Waters Senior Research Scientist, Computational Biology & Bioinformatics Pacific Northwest National Laboratory |
3:00 |
Break |
3:15 |
Integrating Global Gene Expression and Survival Across 60 Cell Lines: Applications for Risk Assessment |
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Albert J. Fornace, Jr. Professor, Department of Biochemistry and Molecular and Cellular Biology, Biomedical Graduate Research Organization; Department of Oncology, Lombardi Comprehensive Cancer Center Georgetown University |
3:45 |
The FDA Experience in Analyzing Genomic Data |
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Federico Goodsaid Associate Director for Operations in Genomics U.S. Food and Drug Administration |
4:15 |
Panel Discussion |
5:30 |
Adjourn |
WEDNESDAY, MAY 13, 2009
WHAT THE FUTURE HOLDS
Moderator: Lorenz Rhomberg, Chair, Symposium Planning Committee; Member, Standing Committee on Risk Analysis Issues and Reviews; Principal, Gradient Corporation |
|
8:30 |
Are we “there” yet and Where is “there”? The Path Forward (1, 5, and 10 years in the future) |
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A Perspective from EPA Peter Preuss Director, National Center for Environmental Assessment U.S. Environmental Protection Agency |
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A Perspective from NIEHS John Bucher Associate Director, National Toxicology Program National Institute of Environmental Health Sciences |
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A Perspective from the Chemical Industry Tina Bahadori Managing Director Long Range Research Initiative American Chemistry Council |
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A Perspective from the Pharmaceutical Industry Roger Ulrich Chief Development Officer Calistoga Pharmaceuticals, Inc. |
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A Perspective from Academia Helmut Zarbl Professor of Environmental and Occupational Medicine University of Medicine and Dentistry of New Jersey |
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A Perspective from an Environmental Advocacy Group Gina Solomon Senior Scientist Natural Resources Defense Council |
10:30 |
Break |
10:45 |
Panel Discussion |
11:45 |
Symposium Close |
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Lorenz Rhomberg Chair, Symposium Planning Committee Member, Standing Committee on Risk Analysis Issues and Reviews Principal, Gradient Corporation |
12:00 |
Adjourn |