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The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. THE NATIONAL ACADEMIES PRESS NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. This study was supported by Contract Number N01-OD-4-2136 between the National Institutes of Health and the National Academy of Sciences, Grant Number 60NANB7D6126 from the National Institute of Standards and Technology, and Grant Number N0014-07-1-0557 from the Office of Naval Research. Any opinions, findings, or conclusions expressed in this publication are those of the authors and do not necessarily reflect the views of the agencies that provided support for the project. International Standard Book Number-13: 978-0-309-15442-0 International Standard Book Number-10: 0-309-15442-1 Additional copies of this report are available from the National Academies Press, 500 Fifth Street, N.W., Lockbox 285, Washington, DC 20055; (800) 624-6242 or (202) 334-3313; Internet, http://www.nap.edu. Copyright 2010 by the National Academy of Sciences. All rights reserved. Printed in the United States of America
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