for the use of the scientific community, including researchers in university, industry, or other private-sector research organizations who are conducting such research with non-federal funding. Researchers conducting federally-funded hES cell research should, however, note that the requirements of the National Institutes of Health (NIH)—available at http://stemcells.nih.gov/policy/2009guidelines.htm—supersede these National Academies’ Guidelines for certain sections (as noted below).

1.1
What These Guidelines Cover

1.1(a) These guidelines cover all derivation of hES cell lines and all research that uses hES cells derived from

  1. blastocysts and/or morulae made for reproductive purposes and later obtained for research from in vitro fertilization (IVF) clinics,

  2. blastocysts and/or morulae made specifically for research using IVF,

  3. somatic cell nuclear transfer (NT) into oocytes or by parthenogensis or androgenesis.

1.1(b) Some of the concerns addressed in this report are common to other types of human stem cell research; as such, certain of these Guidelines should also apply to those other types of research. For example,

  1. research that uses human adult stem cells,

  2. research that uses fetal stem cells or embryonic germ cells derived from fetal tissue; such research is covered by federal statutory restrictions at 42 U.S.C. 289g-2(a) and federal regulations at 45 CFR 46.210,

  3. research using hPS cells derived from non-embryonic sources, such as spermatogonial stem cells and “induced pluripotent” stem cells derived from somatic cells by introduction of genes or otherwise (so-called iPS cells), as well as other pluripotent cells yet to be developed; guidelines for hPS cells are collected in Section 7 below.

Recommendations as to which guidelines apply to other hPS cells are collected in a new Section 7 below. Institutions and investigators conducting research with adult and fetal stem cells should also consider which individual provisions of these guidelines are relevant to their research.



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement