of the implanted cells; and the possible effects of the implanted cells on the function of the animal tissue.

  1. Should not be conducted at this time [see Section 1.3(c)]

    1. Experiments that involve transplantation of hPS cells into human blastocysts.

    2. Research in which hPS cells are introduced into nonhuman primate embryos, pending further research that will clarify the potential of such introduced cells to contribute to neural tissue or to the germ line.

7.4
Multipotent Neural Stem Cells

It is also relevant to note that neural stem cells, although not pluripotent, are multipotent and may have the potential to contribute to neural tissue in chimeric animals. ESCRO committees should decide whether they wish to review and monitor such experiments with neural stem cells in a similar fashion.

7.5
Prohibition on Breeding

No animal into which hPS cells have been introduced such that they could contribute to the germ line should be allowed to breed.

7.6
Guidance for Banking and Distribution

Institutions should consider the value of banking and distributing hPS cells using the guidance and rules that are already in place for hES cells and the value of including hPS cell lines in their registries.

8.0
INTERNATIONAL COLLABORATION

If a U.S.-based investigator collaborates with an investigator in another country, the ESCRO committee may determine that the procedures prescribed by the foreign institution afford protections consistent with these guidelines, and the ESCRO committee may approve the substitution of some of or all of the foreign procedures for its own.

9.0
CONCLUSION

The substantial public support for hES cell research and the growing trend by many nonfederal funding agencies and state legislatures to support this field



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