Appendix D
Committee Member and Staff Biographies

COCHAIRS

R. Alta Charo, JD, is the Warren P. Knowles Professor of Law and Bioethics at the University of Wisconsin–Madison, on the faculties of both the Law School and the Medical School. On August 31, 2009, she took leave to serve as a senior policy advisor in the Office of the Commissioner of the U.S. Food and Drug Administration. Professor Charo is the author of nearly 100 articles, book chapters, and government reports on such topics as voting rights, environmental law, family planning and abortion law, medical genetics law, reproductive technology policy, science policy, and medical ethics. She has been a member of the boards of the Alan Guttmacher Institute and the Foundation for Genetic Medicine, a member of the National Medical Advisory Committee of the Planned Parenthood Federation of America, and a member of the ethics advisory boards of the International Society for Stem Cell Research, the Juvenile Diabetes Research Foundation, and WiCell. In 1994, Professor Charo served on the National Institutes of Health Human Embryo Research Panel, and from 1996 to 2001, she was a member of the presidential National Bioethics Advisory Commission. She was a member of the National Academies’ Board on Life Sciences from 2001 until 2007 and since 2006 has been a member of the Institute of Medicine (IOM) Board on Population Health and Public Health Practices. Professor Charo was elected to IOM in 2006.



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Appendix D Committee Member and Staff Biographies COCHAIRS R. Alta Charo, JD, is the Warren P. Knowles Professor of Law and Bioeth- ics at the University of Wisconsin–Madison, on the faculties of both the Law School and the Medical School. On August 31, 2009, she took leave to serve as a senior policy advisor in the Office of the Commissioner of the U.S. Food and Drug Administration. Professor Charo is the author of nearly 100 articles, book chapters, and government reports on such topics as voting rights, environmental law, family planning and abortion law, medical genet- ics law, reproductive technology policy, science policy, and medical ethics. She has been a member of the boards of the Alan Guttmacher Institute and the Foundation for Genetic Medicine, a member of the National Medical Advisory Committee of the Planned Parenthood Federation of America, and a member of the ethics advisory boards of the International Society for Stem Cell Research, the Juvenile Diabetes Research Foundation, and WiCell. In 1994, Professor Charo served on the National Institutes of Health Human Embryo Research Panel, and from 1996 to 2001, she was a member of the presidential National Bioethics Advisory Commission. She was a member of the National Academies’ Board on Life Sciences from 2001 until 2007 and since 2006 has been a member of the Institute of Medicine (IOM) Board on Population Health and Public Health Practices. Professor Charo was elected to IOM in 2006. 37

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Appendix D 38 Richard O. Hynes, PhD, is the Daniel K. Ludwig Professor for Cancer Re- search at the David H. Koch Institute for Integrative Cancer Research and Department of Biology at MIT and a Howard Hughes Medical Institute Investigator. He was formerly head of the Biology Department and then director of the Center for Cancer Research at the Massachusetts Institute of Technology. His research focuses on fibronectins and integrins and the molecular basis of cellular adhesion, both in normal development and in pathological situations, such as cancer, thrombosis, and inflammation. Dr. Hynes’s current interests are cancer invasion and metastasis, angiogenesis, and animal models of human disease states. He is a member of the National Academy of Sciences and the Institute of Medicine and is a fellow of the Royal Society of London and the American Academy of Arts and Sciences. In 1997, he received the Gairdner International Foundation Award. In 2000, he served as president of the American Society for Cell Biology and testi- fied before Congress about the need for federal support and oversight of embryonic stem cell research. He cochaired the 2005 National Academies Guidelines for Human Embryonic Stem Cell Research and is a governor of the Wellcome Trust, UK. MEMBERS Eli Y. Adashi, MD, MS, CPE, FACOG, is professor of medical science and the immediate past dean of medicine and biological sciences and the Frank L. Day Professor of Biology at Brown University. Harvard-educated in Health Care Management (MS, 2005), Dr. Adashi previously served as the John A. Dixon Endowed Presidential Professor and Chair of the Department of Obstetrics and Gynecology at the University of Utah Health Sciences Center. A member of the Council on Foreign Relations, the Council on Population Growth of the World Economic Forum, the Association of American Physi- cians, the Royal College of Obstetricians and Gynaecologists (ad Eundem), and the American Association for the Advancement of Science, Dr. Adashi is a veteran practitioner of women’s health. An adviser to the World Health Organization, the World Bank, the Rockefeller Foundation and the Bill and Melinda Gates Foundation, Dr. Adashi is a recent Franklin fellow and Se- nior Advisor on Global Women’s Health to the Secretary of State Office of Global Women’s Issues headed by Ambassador-At-Large Melanne Verveer. A long-standing NIH-funded scientist and a Research Career Development Awardee, Dr. Adashi is a former Donna Shalala appointee to the National Advisory Council of the Eunice Kennedy Shriver National Institute of Child

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Appendix D 39 Health and Human Development (NICHD). In addition, Dr. Adashi served the NIH as a member of the Reproductive Sciences 5-Year Planning Forum for NICHD, as a member of the selection committee of the Reproductive Scientist Development Program and as a member of the Reproductive En- docrinology Study Section. A former president of the Society for Reproduc- tive Endocrinologists, the Society for Gynecologic Investigation, and the American Gynecological and Obstetrical Society, Dr. Adashi is the author or co-author of over 250 peer-reviewed publications, over 120 book chap- ters/reviews, and 13 books focusing on ovarian biology, ovarian cancer and women’s reproductive health, freedom and rights. Elected to the Institute of Medicine in 1999, Adashi served on consensus committees on Women’s Health Research, Antiprogestins: Assessing the Science and Understand- ing Premature Birth and Assuring Health Outcomes. Dr. Adashi has also served the IOM as a reviewer of New Frontiers in Contraceptive Research, A Comprehensive Review of the DHHS Office of Family Planning Title X Program and Policy Issues in the Development of Personalized Medicine in Oncology. Dr. Adashi is presently serving on the Board of Directors of Physicians for Human Rights and Population Connection as well as on the Board of Governors of Tel Aviv University. A native of Israel, Dr. Adashi received his medical degree in 1973 from the Sackler School of Medicine of Tel Aviv University. After serving a straight medical internship in the same, Dr. Adashi (a naturalized U.S. citizen) com- pleted residency training in obstetrics and gynecology at the New England Medical Center of Tufts University (1974-77). Fellowship training in the subspecialty of reproductive endocrinology and postdoctoral training in reproductive biology followed suit at Johns Hopkins University and at the University of California at San Diego, respectively (1977-81). Brigid L.M. Hogan, PhD, is the George Barth Geller Professor and chair of the Department of Cell Biology, Duke University Medical Center. Before joining Duke, Dr. Hogan was an investigator of the Howard Hughes Medi- cal Institute and Hortense B. Ingram Professor in the Department of Cell Biology at Vanderbilt University Medical Center. Dr. Hogan earned her PhD in biochemistry at the University of Cambridge. She was then a postdoc- toral fellow in the Department of Biology at the Massachusetts Institute of Technology. Before moving to the United States in 1988, Dr. Hogan was head of the Molecular Embryology Laboratory at the National Institute for Medical Research in London. Her research focuses on the genetic control of embryonic development and morphogenesis, using the mouse as a model system. Her laboratory developed methods for deriving mouse pluripotential

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Appendix D 40 embryonic germ cell lines. She was co-chair for science of the 1994 National Institutes of Health Human Embryo Research Panel and a member of the 2001-2002 National Academies Panel on Scientific and Medical Aspects of Human Cloning. Within the last few years, Dr. Hogan has been elected to the Royal Society of London, the American Academy of Arts and Sciences, the Institute of Medicine, and the National Academy of Sciences. Marcia Imbrescia is the owner of Peartree Design, a landscape design firm, and was previously the media director for Drumbeater, a high-technology advertising agency. She holds BA degrees in marketing and journalism and a graduate certificate in landscape design. Ms. Imbrescia has a passion for health advocacy and helping people with illness and disability. She is a past member of the Board of Trustees of the Arthritis Foundation (AF) (2003- 2007), for which she has participated as a volunteer at the chapter and na- tional levels. She served as a member (1996-1998 and 2001) and chairperson (2002-2003) of AF’s American Juvenile Arthritis Organization. In 1992, she received the Volunteer of the Year Award from the Massachusetts Chapter of AF. Her volunteer efforts include program development, conference plan- ning, public speaking, fundraising, and advocacy. Currently, Ms. Imbrescia is an active volunteer with New England Disabled Sports. She served on the National Academies Committee on Guidelines for Human Embryonic Stem Cell Research in 2004-2005. Terry Magnuson, PhD, is Sarah Graham Kenan Professor and chair of the Department of Genetics at the University of North Carolina. He also directs the Carolina Center for Genome Sciences and is the program director of can- cer genetics at the Lineberger Comprehensive Cancer Center. Dr. Magnuson’s research interests include mammalian genetics, genomics, and development. His laboratory has developed a high-throughput system to study the effects of mutations on mouse development with mouse embryonic stem cells. He is particularly interested in the role of chromatin remodeling complexes in such processes as autosomal imprinting, X-inactivation, and anterior-pos- terior patterning of axial structures in mammals. He is an elected member of the American Academy of Arts and Sciences and was a member of the Board of Directors of the Genetics Society of America and of the Society for Developmental Biology. Linda B. Miller, OTR, MS in hospital administration, is president of the Washington, DC–based Volunteer Trustees Foundation, a consortium of not- for-profit hospital governing boards. She has extensive experience in trustee

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Appendix D 41 education, advocacy, and the legal, ethical, and policy issues facing voluntary health care institutions. Recently, she has worked closely with the states’ attorneys general in developing guidelines for protecting the community interest in the sale and conversion of nonprofit hospitals and in designing models for practice and legal oversight. She was elected to membership in the Institute of Medicine (IOM) in 1997. Ms. Miller has been a frequent speaker on health-policy issues and has been published extensively in both the medical and popular press, includ- ing the New England Journal of Medicine, Health Affairs, USA Today, the Washington Post, and the New York Times. She served as a special assistant to the secretary of health, education, and welfare (now the Department of Health and Human Services) and on numerous health-related policy coun- cils and advisory committees, including the National Institutes of Health’s Consensus Panel on Liver Transplantation and, most recently, IOM’s Com- mittee on Spinal Cord Injury. Ms. Miller serves on the Advisory Board of the University of Louisville–based Institute for Cellular Therapeutics, headed by Suzanne Ildstad, which does research in adult bone marrow transplanta- tion, and has been a member of several academic and health-care institu- tions’ boards of governors, including those of Blythedale Children’s Hospital in New York, Capital Hospice in the national capital region, and Cornell University’s Alumni Council. Jonathan D. Moreno, PhD, is the David and Lyn Silfen University Professor of Ethics and professor of medical ethics and of the history and sociology of science at the University of Pennsylvania. He holds a courtesy appoint- ment as professor of philosophy. He is also a senior fellow at the Center for American Progress in Washington, D.C., where edits the magazine Science Progress (www.scienceprogress.org). He was a member of President Barack Obama’s transition team for the Department of Health and Human Services. Moreno is an elected member of the Institute of Medicine/National Academy of Sciences. In 2008 he was designated a National Associate of the National Research Council. He has served as a senior staff member for two presiden- tial advisory commissions, and has given invited testimony for both houses of congress. He was an Andrew W. Mellon post doctoral fellow, holds an hon- orary doctorate from Hofstra University, and is a recipient of the Benjamin Rush Medal from the College of William and Mary Law School. Moreno has served as adviser to the Howard Hughes Medical Institute and the Bill and Melinda Gates Foundation, among many other organizations. Moreno is also a faculty affiliate of the Kennedy Institute of Ethics at Georgetown University and a fellow of the Hastings Center and the New York Academy

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Appendix D 42 of Medicine. He is a past president of the American Society for Bioethics and Humanities. His books include Progress in Bioethics (2010); Science Next: Innovation for the Common Good (2009); Mind Wars: Brain Re- search and National Defense (2006); Undue Risk: Secret State Experiments on Humans (1999); Ethical Guidelines for Innovative Surgery (2006); Is There an Ethicist in the House? (2005); In the Wake of Terror: Medicine and Morality in a Time of Crisis (2003); Ethical and Regulatory Aspects of Clinical Research (2003); Deciding Together: Bioethics and Moral Consensus (1995); Ethics in Clinical Practice (2000); and Arguing Euthanasia (1995). Moreno has published more than 300 papers, reviews and book chapters, and is a member of several editorial boards. Pilar N. Ossorio, PhD, JD, is associate professor of law and bioethics at the University of Wisconsin–Madison and program faculty in the Graduate Program in Population Health at the university. Before taking her position there, she was director of the Genetics Section of the Institute for Ethics at the American Medical Association and taught as an adjunct faculty member at the University of Chicago Law School. For the 2006 calendar year, Profes- sor Ossorio was a visiting professor of law at the University of California, Berkeley Boalt Hall School of Law. Dr. Ossorio received her PhD in microbiology and immunology in 1990 from Stanford University. She went on to complete a postdoctoral fellowship in cell biology at Yale University School of Medicine. Throughout the early 1990s, Dr. Ossorio worked as a consultant for the federal program on the Ethical, Legal, and Social Implications (ELSI) of the Human Genome Project; in 1994, she took a full-time position with the Department of Energy’s ELSI program. In 1993, she served on the Ethics Working Group for President Clinton’s Health Care Reform Task Force. Dr. Ossorio received her JD from the Boalt Hall School of Law in 1997. While there, she was elected to the legal honor society Order of the Coif and received several awards for out- standing legal scholarship. Dr. Ossorio is a fellow of the American Association for the Advance- ment of Science (AAAS), on the Editorial Board of the American Journal of Bioethics, an adviser to the National Human Genome Research Institute on ethical issues in large-scale sequencing, and a member of the University of Wisconsin’s institutional review board for health-sciences research. She is a past member of AAAS’s Committee on Scientific Freedom and Responsibil- ity, a past member of the National Cancer Policy Board in the Institute of Medicine, and a past member or chair of several working groups on genet-

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Appendix D 43 ics and ethics. She has published scholarly articles in bioethics, law, and molecular biology. E. Albert Reece, MD, PhD, is dean of the University of Maryland School of Medicine and vice president for medical affairs at the University of Mary- land, Baltimore. Previously, he was vice chancellor and dean of the Univer- sity of Arkansas College of Medicine. Dr. Reece received his undergraduate degree from Long Island University, his MD (Magna Cum Laude) from New York University, his PhD in biochemistry from the University of the West Indies, and his MBA from the Fox School of Business and Management of Temple University. He completed a residency in obstetrics and gynecology at Columbia University–Presbyterian Hospital and a fellowship in mater- nal-fetal medicine at Yale University School of Medicine. He served on the faculty at Yale for 10 years and was the chairman of the Department of Obstetrics, Gynecology and Reproductive Sciences at Temple University. Dr. Reece has published over 400 journal articles, book chapters, and abstracts and nine textbooks, including Diabetes in Pregnancy, Medicine of the Fetus & Mother, and Fundamentals of Obstetric & Gynecologic Ultrasound. He is an editor for the Journal of Maternal-Fetal Medicine and a reviewer for several other scientific journals. His research focuses on diabetes in preg- nancy, birth defects, and prenatal diagnosis. Dr. Reece is a member of the Institute of Medicine. Joshua R. Sanes, PhD, is professor of molecular and cellular biology and the Paul J. Finnegan Family Director of the Center for Brain Science at Harvard University. He was previously Alumni Endowed Professor of Neurobiology at the Washington University School of Medicine. Dr. Sanes earned a BA in biochemistry and psychology at Yale and a PhD in Neurobiology at Har- vard. He studies the formation of the synapses that interconnect nerve cells, including pioneering work on the signals exchanged between nerve cells and their target muscles as new connections are made. He is also using the vertebrate visual system to examine how nerve cells develop and migrate to the right location in the body. He has been elected a fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences and the American Academy of Arts and Sciences. Harold T. Shapiro, PhD, is president emeritus of both Princeton University and the University of Michigan and is currently professor of economics and public affairs at Princeton University. His research interests include bioethics, the social role of higher education, hospital and medical- center administra-

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Appendix D 44 tion, university administration, econometrics, statistics, and economics. Dr. Shapiro chaired the Board of Trustees of the Alfred P. Sloan Foundation, was presiding director for the Dow Chemical Company, and is a member of nu- merous boards, including the Robert Wood Johnson Medical School, HCA, the Merck Vaccine Advisory Board, the Knight Foundation Commission on Intercollegiate Athletics, the U.S. Olympic Committee, and the Stem Cell Institute of New Jersey. He is a former chair of the Association of American Universities and the National Bioethics Advisory Committee and vice chair of the President’s Council of Advisors on Science and Technology. He has also served on the Board of Directors of the National Bureau of Economic Research, Inc. and the Board of Trustees of the Universities Research As- sociation, Inc. He has chaired and served on numerous National Academies committees, including the Committee on the Organizational Structure of the National Institutes of Health and the Committee on Particle Physics. Dr. Shapiro was named the 2006 American Association for the Advancement of Science William D. Carey Lecturer for his leadership in science policy. He earned a PhD in economics from Princeton University and holds 14 honor- ary doctorates. John E. Wagner, Jr., MD, is a professor of pediatrics at the University of Minnesota Medical School. He is the first recipient of the Children’s Cancer Research Fund/Hageboeck Family Chair in Pediatric Oncology and also holds the University of Minnesota McKnight Presidential Chair in Can- cer Research. He is the director of the Division of Pediatric Hematology/ Oncology and Bone Marrow Transplantation and scientific director of clini- cal research of the Stem Cell Institute. Dr. Wagner is a member of numerous societies, including the American Society of Hematology, the International Society of Experimental Hematology, and the American Society of Blood and Marrow Transplantation. He is a member of several honorary societ- ies, including Alpha Omega Alpha (1980), the American Society of Clinical Investigation (2000), and the Association of American Physicians (2006). Dr. Wagner holds a patent on the isolation of the pluripotential quiescent stem cell population. Dr. Wagner holds a BA in biological sciences and a BA in psychology from the University of Delaware and an MD from Jefferson Medical College. Dr. Wagner’s research has focused on the development of novel cellular therapies for tissue repair and suppression of the immune response using subpopulations of neonatal umbilical cord blood and adult bone marrow and peripheral blood. His projects are funded by the Na- tional Institutes of Health and industry. In addition, Dr. Wagner pioneered the use of embryo selection to “create” a perfectly tissue-matched stem cell

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Appendix D 45 donor for the treatment of genetic disease. Dr. Wagner has written more than 250 articles and book chapters in the field of hematopoietic stem cell transplantation. He previously served as a member of the Scientific Board of Directors of the National Marrow Donor Program and on the Institute of Medicine’s Committee on Establishing a National Cord Blood Stem Cell Banking Program. He is currently a member of the Scientific and Medical Accountability Standards Working Group of the California Institute of Re- generative Medicine. STAFF Adam P. Fagen, PhD, is a senior program officer with the Board on Life Sciences of the National Research Council. He came to the National Acad- emies from Harvard University, where he most recently served as preceptor on molecular and cellular biology. He earned his PhD in molecular biology and education from Harvard, working on issues related to undergraduate science courses; his research focused on mechanisms for assessing and en- hancing introductory science courses in biology and physics to encourage student learning and conceptual understanding, including studies of active learning, classroom demonstrations, and student understanding of genetics vocabulary. Dr. Fagen also received an AM in molecular and cellular biol- ogy from Harvard, based on laboratory research in molecular evolutionary genetics, and a BA from Swarthmore College with a double-major in biology and mathematics. He served as co-director of the 2000 National Doctoral Program Survey, an on-line assessment of doctoral programs organized by the National Association of Graduate-Professional Students, supported by the Alfred P. Sloan Foundation, and completed by over 32,000 students. At the National Academies, Dr. Fagen has served as study director for Bridges to Independence: Fostering the Independence of New Investigators in Biomedical Research (2005), Treating Infectious Diseases in a Microbial World: Report of Two Workshops on Novel Antimicrobial Therapeutics (2006), 2007 and 2008 Amendments to the National Academies’ Guide- lines for Human Embryonic Stem Cell Research (2007, 2008), Understand- ing Interventions that Encourage Minorities to Pursue Research Careers: Summary of a Workshop (2007), Inspired by Biology: From Molecules to Materials to Machines (2008), Transforming Agricultural Education for a Changing World (2009), Responsible Research with Biological Select Agents and Toxins (2009), and Research at the Intersection of the Physical and Life Sciences (2010). He is currently study director or responsible staff officer for several ongoing projects including the National Academies Summer

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Appendix D 46 Institute on Undergraduate Education in Biology, the National Academies Human Embryonic Stem Cell Research Advisory Committee, and the Special Immunizations Program for Laboratory Personnel Engaged in Research on Countermeasures for Select Agents. Bruce M. Altevogt, PhD, is a senior program officer in the Board on Health Sciences Policy at the Institute of Medicine (IOM). His primary interests focus on policy issues related to basic research and preparedness for cata- strophic events. He received his doctoral thesis from Harvard University’s Program in Neuroscience. Following over 10 years of research, Dr. Altevogt joined The National Academies as a science and technology policy fellow with the Christine Mirzayan Science & Technology Policy Graduate Fel- lowship Program. Since joining the Board on Health Sciences Policy, he has been a program officer on multiple IOM studies including, Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem, The National Academies’ Guidelines for Human Embryonic Stem Cell Research: 2007 Amendments and 2008 Amendments, and Research Priorities in Emergency Preparedness and Response for Public Health Systems. He is currently serv- ing as the director of the Forum on Medical and Public Health Preparedness for Catastrophic Events, the Neuroscience and Nervous System Disorders Forum, and as a co-study director on the National Academies Human Em- bryonic Stem Cells Research Advisory Committee. He received his BA from the University of Virginia in Charlottesville, where he majored in biology and minored in South Asian studies. Frances E. Sharples, PhD, has served as director of the National Research Council’s Board on Life Sciences since October 2000. Immediately prior to this position, she was a senior policy analyst for the Environment Division of the White House Office of Science and Technology Policy (OSTP) for four years. Dr. Sharples came to OSTP from the Oak Ridge National Laboratory, where she served in various positions in the Environmental Sciences Divi- sion between 1978 and 1996, most recently as a Research and Development Section Head. Dr. Sharples received her BA in biology from Barnard College and her MA and PhD in zoology from the University of California, Davis. She served as an American Association for the Advancement of Science (AAAS) Environmental Science and Engineering Fellow at the Environmen- tal Protection Agency during the summer of 1981, and served as a AAAS Congressional Science and Engineering Fellow in the office of Senator Al Gore in 1984-85. She was a member of the National Institutes of Health’s

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Appendix D 47 Recombinant DNA Advisory Committee in the mid-1980s, and was elected a Fellow of the AAAS in 1992. Andrew M. Pope, PhD, is director of the Board on Health Sciences Policy in the Institute of Medicine (IOM). He has a PhD in physiology and bio- chemistry from the University of Maryland and has been a member of the National Academies staff since 1982 and of the IOM staff since 1989. His primary interests are science policy, biomedical ethics, and environmental and occupational influences on human health. During his tenure at the National Academies, Dr. Pope has directed numerous studies on topics that range from injury control, disability prevention, and biologic markers to the protection of human subjects of research, National Institutes of Health priority-setting processes, organ procurement and transplantation policy, and the role of science and technology in countering terrorism. Dr. Pope is the recipient of IOM’s Cecil Award and the National Academy of Sciences President’s Special Achievement Award. Amanda P. Cline, is a senior program assistant with the Board on Life Sci- ences at the National Academies. She earned a BS in environmental studies from Bucknell University in 2006.

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