membership in the American Society of Clinical Investigation. He is editor for Antimicrobial Agents and Chemotherapy, on the editorial board of Microbial Drug Resistance, an editor of the Sanford Guide to Antimicrobial Therapy, a reviewer for numerous medical publications, and a peer reviewer for National Institutes of Health (NIH) study sections. He has been a member of advisory groups for the Centers for Disease Control and Prevention (CDC) and a member of IDSA treatment guidelines committees. His clinical and research interests are anti-microbial drug resistance, staphylococcal infections, experimental therapeutics, and epidemiology and pathogenesis of disease caused by community-acquired methicillin-resistant Staphylococcus aureus. He has over 200 publications and textbook chapters in the areas of drug resistance, endocarditis, bacterial infections, and staphylococcal diseases.

James J. Collins, Ph.D., is an investigator in the Howard Hughes Medical Institute, and a William F. Warren Distinguished Professor, university professor, professor of biomedical engineering, and co-director of the Center for BioDynamics at Boston University. He is also a core founding faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University. His research group works in synthetic biology and systems biology, with a particular focus on network biology approaches to antibiotic action and bacterial defense mechanisms.

Patrice Courvalin, M.D., is Professor de Classe Exceptionnelle at the Institut Pasteur, where he directs the French National Reference Center for Antibiotics and has been the Head of the Antibacterial Agents Unit since 1983. He and his collaborators are experts in the genetics and biochemistry of antibiotic resistance. In particular, he first described and then elucidated vancomycin resistance in Enterococcus. His research has led to a revision of the dogma describing natural dissemination of antibiotic resistance genes. He and his colleagues demonstrated that a wide variety of pathogenic bacteria can promiscuously exchange the genetic material conferring antibiotic resistance, proved that conjugation could account for dissemination of resistance determinants between phylogenetically remote bacterial genera, elucidated the transposition mechanism of conjugative transposons from Gram-positive cocci, and, more recently, obtained direct gene and protein transfer from bacteria to mammalian cells. His work has been reported in more than 290 publications in international scientific journals.

Julian Davies, Ph.D., is emeritus professor of microbiology and immunology at University of British Columbia. Trained as an organic chemist, he switched to molecular microbiology in 1962 when he joined the Department of Bacteriology and Immunology at Harvard Medical School. Subsequently, he held academic positions at the University of Wisconsin, University of Geneva, and Institut Pasteur before joining the University of British Columbia (UBC) as Head of

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