the Native American populations) individuals per non-Hispanic/Latino population to calculate pairwise F_ST. MAF was set at a threshold >0.1 in the populations compared by F_ST calculations.

We thank Mariano Rey for support of the project; Peter Gregersen, Carole Oddoux, and Annette Lee for technical assistance; and Marc Pybus for valuable programming support during part of the analyses. This work was supported by the National Institutes of Health (Grant 1R01GM83606) as part of the National Institute of General Medical Sciences research funding programs. Genotype data from 100 Hispanic/Latinos have been deposited in the Gene Expression Omnibus (GEO) series record GSE21248.