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try, we binned the SNPs in the Illumina panel on the basis of the allele frequency in Europeans rather than the global allele frequency to calculate the transformed rank statistics.

ACKNOWLEDGMENTS

We thank members of the Di Rienzo laboratory, John Novembre, and Molly Przeworski for helpful discussions during the course of this project; and Molly Przeworski for thoughtful comments on the manuscript. This work was supported by National Institutes of Health (NIH) Grants DK56670 and GM79558 and an International Collaborative Grant from the Wenner-Gren Foundation (to A.D.R.). A.M.H. was supported in part by American Heart Association Graduate Fellowship 0710189Z and by NIH Genetics and Regulation Training Grant GM07197. G.C. was supported in part by a Sloan Research Fellowship. J.K.P. acknowledges support from the Howard Hughes Medical Institute.



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