HIV Infection Listing Introductory Text

14.00A. What disorders do we evaluate under the immune system disorders listings?

  1. We evaluate immune system disorders that cause dysfunction in one or more components of your immune system.

    1. The dysfunction may be due to problems in antibody production, impaired cell mediated immunity, a combined type of antibody/cellular deficiency, impaired phagocytes, or complement deficiency.

    2. Immune system disorders may result in recurrent and unusual infections, or inflammation and dysfunction of the body’s own tissues. Immune system disorders can cause a deficit in a single organ or body system that results in extreme (that is, very serious) loss of function. They can also cause lesser degrees of limitations in two or more organs or body systems, and when associated with symptoms or signs, such as severe fatigue, fever, malaise, diffuse musculoskeletal pain, or involuntary weight loss, can also result in extreme limitation.

    3. We organize the discussions of immune system disorders in three categories: autoimmune disorders; immune deficiency disorders, excluding human immunodeficiency virus (HIV) infection; and HIV infection.

  1. Autoimmune disorders (14.00D). Autoimmune disorders are caused by dysfunctional immune responses directed against the body’s own tissues, resulting in chronic, multisystem impairments that differ in clinical manifestations, course, and outcome. They are sometimes referred to as rheumatic diseases, connective tissue disorders, or collagen vascular disorders. Some of the features of autoimmune disorders in adults differ from the features of the same disorders in children.

  2. Immune deficiency disorders, excluding HIV infection (14.00E). Immune deficiency disorders are characterized by recurrent or unusual infections that respond poorly to treatment, and are often associated with complications affecting other parts of the body. Immune deficiency disorders are classified as either primary (congenital) or acquired. Individuals with immune deficiency disorders also have an increased risk of malignancies and of having autoimmune disorders.

  3. Human immunodeficiency virus (HIV) infection (14.00F). HIV infection may be characterized by increased susceptibility to opportunistic infections, cancers, or other conditions, as described in 14.08.

B. What information do we need to show that you have an immune system disorder? Generally, we need your medical history, a report(s) of a



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