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The Prevention and Treatment of Missing Data in Clinical Trials (2010)
Committee on National Statistics (CNSTAT)

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. "Summary." The Prevention and Treatment of Missing Data in Clinical Trials. Washington, DC: The National Academies Press, 2010.

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The Prevention and Treatment of Missing Data in Clinical Trials

ity analysis and principled decision making based on the results from sensitivity analyses, (2) analysis of data where the missingness pattern is nonmonotone, (3) sample size calculations in the presence of missing data, (4) design of clinical trials, in particular plans for follow-up after treatment discontinuation (degree of sampling, how many attempts are made, etc.), and (5) doable robust methods, to more clearly understand their strengths and vulnerabilities in practical settings. The development of software that supports coherent missing data analyses is also a high priority.

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