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Sequence-Based Classification of Select Agents: A Brighter Line
Appendix D
2009 Workshop Agenda
Scientific Milestones for the Development of a Gene-Sequence-Based Classification System for Oversight of Select Agents
Thursday, Sept. 3rd, 2009
The National Academy of Sciences Building: Lecture Room
2100 C St., N.W. • Washington, D.C. 20037
AGENDA
8:30 a.m.
Welcome and Opening Remarks
James LeDuc, committee chair—The University of Texas Medical School
The workshop in context of the study and the statement of task
9:00 a.m.
Session 1: The Current Structure for Oversight
What are the current forms of oversight? Are there gaps in the oversight, and if so, are these gaps emerging as a result of new technology, new user communities, or new perceptions? How might a sequence based system be helpful in addressing these gaps/concerns?
*Moderator: Rachel Levinson
• Julia Kiehlbauch, United States Department of Agriculture, Animal and Plant Health Inspection Service
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• Rob Weyant, Centers for Disease Control and Prevention—Synthetic DNA and the Select Agent Regulations.
• Claudia Mickelson, Massachusetts Institute of Technology—IBC, RAC guidelines and concerns about sequences.
• Edward You, Federal Bureau of Investigation—Surveillance of Select Agent list and emerging concerns.
• Amy Patterson, National Institutes of Health, Office of Biotechnology Activities—Comprehensive view and the need for this study.
Panel discussion: ~30 min
10:30 a.m.
Break
10:45 a.m.
Session 2: Current Mechanisms and Criteria for Screening and Surveillance
What is currently being done? How are sequences chosen to monitor? What is a “sequence of concern”?
*Moderator—John Mulligan
• Pete Pesenti, Department of Homeland Security—What are the factors and process used for risk assessment? What are the criteria or characteristics of agents (or sequences) considered a threat?
• John Mulligan, Blue Heron Biotechnology—What are the current screening practices, standards, and procedures in the industry? What are challenges and concerns?
• Marcus Graf, GeneArt and Claes Gustafsson, DNA 2.0—Representing companies working to harmonize screening techniques. What would they like to know to help the decision making process?
• Stephen M. Maurer, University of California at Berkeley—Interface of biosecurity, synthetic biology, and industry.
Panel discussion: ~30 min ** Ed You, FBI will join panel **
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12:15 p.m.
Lunch
1:00 p.m.
Session 3: Virulence
What is virulence? Why is it so hard to predict? What attributes make a pathogen a threat to biosecurity? —to public health? Is there a difference?
*Moderator—Stan Falkow
• Stan Falkow, Stanford University—Overview of virulence, meaning of genomics in prediction.
• Jeff Taubenberger, National Institutes of Health, National Institute of Allergy and Infectious Diseases—Influenza virulence and the role of genotype-phenotype relationships.
• Michael Katze, University of Washington—Systems biology and the difficulty predicting the importance of a sequence.
• Ralph Baric, University of North Carolina at Chapel Hill—SARS, systems genetics and pathogenesis.
• Ramon Felciano, Ingenuity Systems—Systems biology and pathway modeling of pathogenesis and host response.
Panel discussion: ~30 min
3:10 p.m.
Break
3:25 p.m.
Session 4: Predicting Pathogenicity from Sequence
Speakers will address gaps, challenges, and timeframe for milestones.
*Moderator—Sean Eddy
• Sean Eddy, Howard Hughes Medical Institute, Janelia Farm Research Campus—Overview of sequence analysis; how reliably can protein function be predicted from protein sequence?
• Jonathon Eisen, University of California at Davis—Phylogenomic inference of protein function and the importance of genomic context.
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• Elliot J Lefkowitz, University of Alabama at Birmingham—Bioinformatics support for pathogen research; Viral gene discovery and pathogenic potential.
• John Moult, University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology—Protein structure and function prediction.
• Ian Lipkin, Columbia University, Mailman School of Public Health—Identification of emerging or novel microorganisms—pathogen surveillance.
Panel discussion: ~30 min
5:45 p.m.
Closing Remarks
6:00 p.m.
Adjourn
