construction of rigid lists that reflect biological reality poorly and therefore can provide only limited utility for national security. Thus, in Chapter 3 we discuss how the Select Agent list might be clarified by sequence-based classification to better circumscribe the taxonomic distinctions blurred by natural and synthetic variation and modification. Moreover, we present a “yellow flag” biosafety system; this approach is not regulatory and therefore could provide sequence information relevant to biosecurity in a more dynamic and timely manner than the Select Agent Regulations.

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