Comment Reference

Brock, W.J., G.M. Rusch, and H.J. Trochimowicz. 2003. Cardiac sensitization: Methodology and interpretation in risk assessment. Regul. Toxicol. Pharmacol. 38(1):78-90.

COMMENTS PERTAINING TO ALL TSDs

For all TSDs, when substantial discrepancies are found between AEGL values and other guideline values (e.g., IDLHs, STELs, and WEELs), the possible reasons should be explored and discussed.

It is important that the TSD summaries be updated to reflect revisions to the main text of the TSDs.

For chemicals thought to be direct-acting respiratory irritants, an uncertainty factor of 3 to account for intraspecies differences is often used rather than a default factor of 10. This is usually supported by a statement that response to sensory irritants is not expected to vary greatly among individuals. However, there is often wide variability in responses to such chemicals. Better justification and supporting references should be provided for departing from the default value of 10 (see Standing Operating Procedures [NRC 2001, pages 87-88]).

Comment Reference

NRC (National Research Council). 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: National Academy Press.



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