BOX 2-3

Office of Research on Women’s Health Neuroscience Working Group Recommendations

  1. Promote recognition and understanding of sex differences in brain function and brain disorders in neuroscience graduate and medical school training curriculums.

  2. Convene a panel of experts to make recommendations to the National Institutes of Health Peer Review administration on the inclusion of female subjects and/or focus on sexually differentiated brain function and disease in basic neuroscience research.

  3. Develop new paradigms to study the epigenetic influences impacting development of neurological and psychiatric disorders. What determines sex-specific or sex-biased brain disease vulnerability, course, and/or response to therapeutics?

    • Develop experimental paradigms that model sex-specific or sex-biased experiential, hormonal, and psychosocial effects on gene expression, and intra- and intercellular signaling properties in the brain.

    • Develop and use high-throughput epigenomic approaches to characterize the large-scale epigenetic alterations associated with experience and related to sexually differentiated brain function and disease.

  1. Develop new paradigms and molecular genetic approaches to study the impact of experience, hormones, developmental stage, and aging on sex differences in steroid hormone signaling in vivo; these could include new generations of transgenic and gene targeting approaches.

  2. Develop and support new approaches to define similarities and differences in sexually differentiated brain function and disease in human and animal models, for example, through the use of comparative imaging of sexually differentiated brain function.

  3. Develop new methodologies for targeted imaging and application of pharmacological agents to sexually differentiated cell populations in the brain.



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