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evidence of cognitive improvement especially if those biomarkers are, in actuality, surrogate markers.

The information e-infrastructure described by Frisoni would seem appropriate for any project, and ultimately could serve the needs of researchers of all neurodegenerative conditions to accumulate and share relevant data around the globe.

Panelists noted their concerns that resources may still be constrained, and broadening ADNI efforts beyond AD could create competition for funding. The sentiment was that there is a need to push for targeted funding of a longitudinal study of a presymptomatic AD cohort, and to identify novel ways to engage industry and incentivize long-term investment in study of the prodromal cohort.

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