• Hypertension 2007, not VA service connected

  • Ischemic heart disease (category change from Update 2006), 2009, 2009

  • Type 2 diabetes (mellitus), 2000, 2001

  • Spina bifida in offspring of exposed people, 1996, 1996

Inadequate or Insufficient Evidence to Determine an Association

The available epidemiologic studies are of insufficient quality, consistency, or statistical power to permit a conclusion regarding the presence or absence of an association. For example, studies fail to control for confounding, have inadequate exposure assessment, or fail to address latency. There is inadequate or insufficient evidence to determine an association between exposure to the chemicals of interest and the following health outcomes that were explicitly reviewed:

  • Cancers of the oral cavity (including lips and tongue), pharynx (including tonsils), or nasal cavity (including ears and sinuses)

  • Cancers of the pleura, mediastinum, and other unspecified sites in the respiratory system and intrathoracic organs

  • Esophageal cancer

  • Stomach cancer

  • Colorectal cancer (including small intestine and anus)

  • Hepatobiliary cancers (liver, gallbladder, and the bile ducts)

  • Pancreatic cancer

  • Bone and joint cancer

  • Melanoma

  • Nonmelanoma skin cancer (basal-cell and squamous-cell)

  • Breast cancer

  • Cancers of the reproductive organs (cervix, uterus, ovary, testis, and penis; excluding prostate)

  • Urinary bladder cancer

  • Renal cancer (kidney and renal pelvis)

  • Cancers of brain and nervous system (including eye)

  • Endocrine cancers (thyroid, thymus, and other endocrine organs)

  • Leukemia (other than all chronic B-cell leukemias, such as chronic lymphocytic leukemia and hairy-cell leukemia)

  • Cancers at other and unspecified sites

  • Infertility

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