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Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
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Appendix A


Agenda

THE NEW PROFILE OF DRUG RESISTANT TUBERCULOSIS: A GLOBAL AND LOCAL PERSPECTIVE

Sponsored by the U.S. National Academy of Sciences, Institute of Medicine, Forum on Drug Discovery, Development, and Translation, and the Russian Academy of Medical Sciences, this 2-day workshop will address the spread of multidrug-resistant (MDR) tuberculosis in Russia and across the globe, as well as the rapid emergence and spread of extensively drug resistant (XDR) tuberculosis. The implications of totally drug resistant (TDR) tuberculosis will also be discussed, as well as the newly emerging profile of MDR TB.

Objectives: The primary goals of this workshop are:

  • to increase awareness and create a renewed sense of urgency of the growing global burden of multidrug- and extensively drug-resistant tuberculosis (MD/XDR TB) and its profile in Russia;
  • to consider the magnitude of transmission of drug-resistant strains and options for transmission and infection control;
  • to address the MDR TB burden in vulnerable populations, including pediatric cases, those co-infected with HIV, and substance abusers;
  • to assess current treatment options and approaches to patient care, taking into account the unique needs of the population being treated;
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
  • to discuss the supply of quality-assured second-line TB drugs and the pipeline for a new “cocktail” of TB drugs;
  • to assess the current state of the art for rapid detection of drug resistance—and its implication for patient management; and
  • to suggest policies to accelerate improvements in drug-resistant TB treatment and infection control.

Wednesday, May 26

Conference Venue: International Science & Technology Centre (ISTC)
Krasnoproletarskaya ulitsa, 32-34
127473 Moscow, Russia

09:00–09:30 Welcoming Remarks and Overview of Conference Objectives

Dmitry Orlov, Russian Academy of Medical Sciences
Mikhail Perelman, Moscow Medical Academy
Gail Cassell, Eli Lilly and Company

   
09:30–12:30 Roundtable #1: Magnitude of the Burden of Drug Resistant Tuberculosis—Local and Global Perspectives

Co-Chairs: Marina Yakimova, Central TB Research Institute
Jeffrey Drazen, New England Journal of Medicine

   
  Global Status of MDR/XTR Tuberculosis, 30 min

Salmaan Keshavjee, Chair, Green Light Committee (GLC)
Harvard Medical School

  Epidemiology of TB in the Russian Federation, 30 min

Marina Yakimova, Central TB Research Institute

   
  Prevalence of Drug Resistance at the Initiation of Second-Line Drugs in Eight Countries, 30 min

Peter Cegielski, U.S. Centers for Disease Control and Prevention

   
  Profile of MDR/XDR in South Africa Based Upon Laboratory Data, 30 min

Gerrit Coetzee, National Health Laboratory Service, South Africa

Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
  Current Status of Disease Burden and Programmatic Management of MDR/XDR TB in China, 30 min

Mingting Chen, Center for Disease Control and Prevention, China

   
  Roundtable Discussion, 30 min
   
12:30–13:30 Lunch
   
13:30–15:30 Roundtable #2: The Capability of Health Care Systems to Keep Up with the Spread of MDR TB

Co-Chairs: Elena Skachkova, Central Research
Institute for the Organization and
Informatization of Health Care, Moscow

Dale Nordenberg, Novasano Health and Science

   
  Monitoring System of MDR TB, 30 min

Elena Skachkova, Central Research Institute for the Organization and Informatization of Health Care, Moscow

   
  Surveillance Systems for TB Drug Resistance in China, 30 min

Renzhong Li, Center for Disease Control and Prevention, China

   
  Laboratory lnformation Barriers to MDR TB Control, 30 min

Dale Nordenberg, Novasano Health and Science

   
  Roundtable Discussion, 30 min
   
15:30 – 15:45 Break
   
15:45 – 17:45 Roundtable #3: Treatment of Drug-Resistant TB in Vulnerable Patient Populations

Co-Chairs: Irina Vasilyeva, Central TB Research Institute
Janet Tobias, Ikana Media

   
  Treatment of MDR TB, the CTRI Experience, 15 min

Irina Vasilyeva, Central TB Research Institute

Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
  Approach to the Treatment of Children Infected with Multidrug-Resistant TB, 15 min

Elena Ovsiankina,1Central TB Research Institute

   
  HIV and MDR TB Co-Infection, 15 min

Olga Frolova, Federal Center of TB/AIDS Treatment

   
  MDR TB in Cases of Substance Abuse, 15 min

Piotr Golubchikov, Regional Anti-Tuberculosis Dispensary, Tomsk

   
  Epidemiology of TB in the Prison System of the Russian Federation, 15 min

Svetlana Safonova, Federal Correction System, Russian Federation

   
  Response Panel and Roundtable Discussion, 45 min

Sonya Shin, Harvard Medical School

Carlos Pérez-Vélez, National Jewish Hospital, Denver

Gary Reubenson, Rahima Moosa Mother & Child

Hospital, South Africa

   
17:45–18:30 Gaps in TB Research: Meeting Report from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)

Barbara Laughon, NIAID/NIH

Alexandr Apt, Central Institute for Tuberculosis, Moscow

   
  Opportunities for International Cooperation

Stuart Politi, Civilian Research and Development Foundation

 

 

images

1 Unable to attend the workshop due to an emergency.

Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×

Thursday, May 27

Conference Venue: International Science & Technology Centre (ISTC)
Krasnoproletarskaya ulitsa, 32-34
127473 Moscow, Russia

08:30–10:10 Roundtable #4: Rapid Methods for Determining Drug Resistance in Tuberculosis and Implications for Patient Management

Co-Chairs: Elena Larionova, Central TB Research Institute
Jerrold Ellner, Division of Infectious
Diseases, Boston University

   
  Molecular and Genetic Methods of Mycobacteria Identification in Russia, 20 min

Tatiana Smirnova, Central TB Research Institute

   
  Overview of Rapid Methods for Determining Drug Resistance in Mycobacterium tuberculosis, 20 min

Elena Larionova, Central TB Research Institute

   
  Implication of Rapid Detection of Resistance in Patient Management, 20 min

Danila Zimenkov, Engelhardt lnstitute of Molecular Biology, Moscow

   
  Response Panel and Roundtable Discussion, 40 min

Maria Giovanni, National Institute of Allergy and Infectious Diseases, National Institutes of Health Nico Gey van Pittius, Stellenbosch University, South Africa

Qian Gao, Shanghai Medical College, China

   
10:10–12:00 Roundtable #5: MDR TB Transmission and Infection Control

Co-Chairs: Rostislav Mitrofanov, Novosibirsk
Tuberculosis Research Institute

Edward Nardell, Harvard Medical School

   
  Infection Control in Anti-Tuberculosis Institutions, 20 min

Elina Sevastyanova, Central TB Research Institute

Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
  Transmission of MDR/XDR in Shanghai, 20 min

Qian Gao, Shanghai Medical College, China

   
  Transmission-Based Genetic Analysis in South Africa, 20 min

Nico Gey van Pittius, Stellenbosch University, South Africa

   
  Turning off the Spigot: Reducing Nosocomial Drug-Resistant TB Transmission, 20 min

Edward Nardell, Harvard Medical School

   
  Roundtable Discussion, 30 min
   
12:00–13:00 Lunch
   
13:00 – 13:50 Roundtable #6: lnnovative Efforts to Advance MDR TB Control and Treatment

Co-chairs: Vladislav Gergert, Central SRI of TB, RAMS
Jeffrey Drazen, New England Journal of Medicine

   
  Stem Cell TB Therapy Application in Experiment, 20 min

Vladislav Gergert, Central SRI of TB, RAMS

   
  Stem Cell Therapy in MDR TB Patients: A Promising Approach? 20 min [via online presentation]

Mark Maeurer, Karolinska Institute

   
  Roundtable Discussion, 10 min
13:50–14:35 Roundtable #7: Addressing Challenges in MDR TB Drug Procurement

Co-chairs: Nikita Afanasiev, USAID, Moscow
Paul Zintl, Partners In Health

   
  The World Health Assembly Resolution on MDR/XDR TB: Is It Important for Russia’s Second-Line TB Drug Supply? 15 min

Paul Zintl, Partners In Health

Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
  Response Panel and Roundtable Discussion, 30 min

Dmitry Goliaev, Russian Health Care Foundation
Alex Golubkov, Partners In Health
Benjamin Potashnikov, Biocom, Russia

   
14:35–15:00 Break
   
15:00–18:15 Roundtable #8: Closing Plenary Lectures: A Blueprint for Action
  Chair: Gail Cassell, Eli Lilly and Company
   
  Remarks from Academician Mikhail Perelman, Moscow Medical Academy
   
  The Realities of Global MDR TB Control and the Growing Number of Totally Resistant Cases (XDR TB): An Argument for Quantifying the Threat in Tangible Ways

Paul Farmer, Partners In Health

   
  The Critical Role of Regulatory Science and Innovation in Making Existing Drugs Matter and in Development of New TB Drugs and Diagnostics

Margaret Hamburg, Commissioner, U.S. Food and Drug Administration
Former Public Health Commissioner, New York City

   
  Summary of Meeting Highlights and a Blueprint for Action

Salmaan Keshavjee, Green Light Committee (GLC) Initiative

   
  Response Panel and Roundtable Discussion

Peter Cegielski, U.S. Centers for Disease Control and Prevention
Mingting Chen, Center for Disease Control and Prevention, China
Gerrit Coetzee, National Health Laboratory Service, South Africa
Janet Tobias, Ikana Media

   
18:15–18:30 Closing Remarks
Gail Cassell, Eli Lilly and Company
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×

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Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
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Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
Page 114
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
Page 115
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
Page 116
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
Page 117
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
Page 118
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
Page 119
Suggested Citation:"Appendix A: Agenda." Institute of Medicine. 2011. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science. Washington, DC: The National Academies Press. doi: 10.17226/13033.
×
Page 120
Next: Appendix B: Summary of a Meeting of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Held May 2425, 2010, Moscow, Russian Federation »
The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop by the Institute of Medicine and the Russian Academy of Medical Science Get This Book
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An estimated 2 billion people, one third of the global population, are infected with Mycobacterium tuberculosis, the bacterium that causes tuberculosis. Spread through the air, this infectious disease killed 1.7 million in 2009, and is the leading killer of people with HIV. Tuberculosis (TB) is also a disease of poverty--the vast majority of tuberculosis deaths occur in the developing world. Exacerbating the devastation caused by TB is the growing threat of drug-resistant forms of the disease in many parts of the world.

Drug-resistant tuberculosis presents a number of significant challenges in terms of controlling its spread, diagnosing patients quickly and accurately, and using drugs to treat patients effectively. In Russia in recent decades, the rise of these strains of TB, resistant to standard antibiotic treatment, has been exacerbated by the occurrence of social, political, and economic upheavals. The Institute of Medicine (IOM) Forum on Drug Discovery, Development, and Translation, in conjunction with the Russian Academy of Medical Sciences held a workshop to discuss ways to fight the growing threat of drug-resistant TB. The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop presents information from experts on the nature of this threat and how it can be addressed by exploring various treatment and diagnostic options.

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