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Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
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Acronyms

α-CD20

anti-CD20, CD20 is cluster of differentiation 20, a cell surface protein

α-CD33

anti-CD33, CD33 is cluster of differentiation 33

ADME

absorption, distribution, metabolism, excretion

Apo-A1

apolipoprotein A1

ASTM

organization formerly known as the American Society for Testing and Materials



βhCG

β subunit of human chorionic gonadotropin

BNP

brain natriuretic peptide

CAS

Chinese Academy of Sciences

CBEN

Center for Biological and Environmental Nanotechnology

CCNE

Center of Cancer Nanotechnology Excellence

CEN

European Committee for Standardization

CFU-GM

colony-forming unit granulocyte macrophage

CK-MB

creatine kinase MB fraction (the MB fraction is most specific to cardiac muscle)

CLIO-Cy5.5

cross-linked iron oxide Cy5.5 (Cy5.5 is a type of cyanine fluorescent dye)

DARPA

Defense Advanced Research Projects Agency

DEAL

DNA-encoded antibody barcode

Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
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DFMO

difluoromethylornithine

DNA

deoxyribonucleic acid

DOX-OXD dextran conjugated doxorubicin
Doxorubicin-cBR96

doxorubicin conjugated to chimeric

(α-CD174)

monoclonal antibody cBR96 (anti-CD174, CD174 is cluster of differentiation 174, a cell surface protein)

DTA-IL2

fusion fusion protein of diphtheria toxin fragment A

protein (α-CD25)

and interleukin 2 (this fusion protein targets CD25, a cell surface protein)

EGCG

epigallocatechin-3-gallate

EGF

epidermal growth factor

EGFR

epidermal growth factor receptor

ELISA

enzyme-linked immunosorbent assay

EMEA

European Medicines Agency

EPA

Environmental Protection Agency

EUFETS

a European contract manufacturer for cell and gene therapy

FDA

Food and Drug Administration

Genexol-PM

Genexol–polymeric micelle

GFP

green fluorescent protein

GM-CSF

granulocyte-macrophage colony stimulating factor

GMP

good manufacturing practices

gp60

60 kDa glycoprotein, an albumin binding protein

hCG

human chorionic gonadotrophin

HER2

human epidermal growth factor receptor 2

Hg

mercury

IBBC

integrated blood barcode chip

ICH

International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use

ICON

International Council on Nanotechnology

IFN-γ

interferon-γ

IL-1α

interleukin-1α

IL-1β

interleukin-1β

IL-2

interleukin-2

Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
×
IL-6

interleukin-6

IL-10

interleukin-10

IL-12

interleukin-12

IND

Investigational New Drug Application

IOM

Institute of Medicine

ISO

International Organization for Standardization

IV

intravenous

KS

Kaposi sarcoma

LD50

median lethal dose

LE-SN38

liposome-encapsulated 7-Ethyl-10-hydroxy-camptothecin

LErafAON

liposome encapsulated c-raf antisense oligonucleotide

LMWP

low molecular weight peptide

MALDI TOF MS

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

MCP-1

monocyte chemotactic protein-1

MFNP

magneto/fluorescent nanoparticles

MIT

Massachusetts Institute of Technology

MR

magnetic resonance

MRI

magnetic resonance imaging

MTX-HSA

human serum albumin–bound methotrexate nab nanoparticle albumin-bound

NCI

National Cancer Institute

NCL

Nanotechnology Characterization Laboratory

NIH

National Institutes of Health

NIST

National Institute of Standards and Technology

NK911

polymeric micelle carrier system for doxorubicin

NMR

nuclear magnetic resonance

NNI

National Nanotechnology Initiative

NSAIDs

non-steroidal anti-inflammatory drugs

NSFC

National Natural Science Foundation of China

OECD

Organisation for Economic Co-operation and Development

Onco-TCS

Onco-transmembrane carrier system, the drug vincristine

Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
×
OSHA

Occupational Health and Safety Administration

OSI-211

liposomal lurtotecan drug manufactured by

OSI

Pharmaceuticals

P13K

phosphatidylinositol 3-kinase

PEG

polyethylene glycol

PEG-IFNα2a/-IFNα2b

pegylated interferon α-2a/interferon α-2b

PEG-L-asparaginase

polyethylene glycol conjugated asparaginase

PGA-paclitaxel

polyglutamic acid conjugated paclitaxel

PHPMA-doxorubicin

poly(2-hydroxypropyl methacrylate) conjugated doxorubicin

PK

pharmacokinetics

PK1

N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin

PK2

N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer backbone and pendant doxorubicin (DOX) linked via a Gly-Phe-Leu-Gly peptide spacer

PLD-E1A

pegylated liposomal doxorubicin–linked E1A (an adenoviral oncogene) plasmid DNA

PLGA

polylactic-co-glycolic acid

PRINT

particle replication in non-wetting templates

PSA

prostate specific antigen

RBC

red blood cell

RES

reticuloendothelial system

RNA

ribonucleic acid

RNAi

RNA interference

SGN-15

cBR96-doxorubicin immunoconjugate, SGN stands for Seattle Genetics Inc.

siRNA

short interfering RNA or silencing RNA

SPARC

secreted protein, acidic and rich in cysteine

SPI-77

sterically stabilised liposomal cisplatin

TGF-β

transforming growth factor β

TNF

tumor necrosis factor

TNF-γ

tumor necrosis factor γ

UK

United Kingdom

WBC

white blood cell

Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
×
Page 73
Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
×
Page 74
Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
×
Page 75
Suggested Citation:"Acronyms." Institute of Medicine. 2011. Nanotechnology and Oncology: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13037.
×
Page 76
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Nanotechnology and Oncology: Workshop Summary Get This Book
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One way scientists are working to overcome challenges in cancer treatment and improve cancer care is through nanotechnology. Nanotechnology, engineered materials that make use of the unique physical properties, presents a new array of medical prospects that will revolutionize cancer prevention, diagnosis, and treatment practices. Giving new hope to patients, practitioners, and researchers alike, nanotechnology has the potential to translate recent discoveries in cancer biology into clinical advances in oncology. While public investments in nanotechnology for cancer continue to increase, medical products based on nanotechnology are already on the market.

The National Cancer Policy forum held a workshop July 12-13, 2010, to explore challenges in the use of nanotechnology in oncology. Nanotechnology and Oncology evaluates the ongoing discussion on the role of nanotechnology in cancer as it relates to risk management, treatment, and regulatory policy. Assessments on nanomedicine and the physical properties of nanomaterials were presented during the workshop, along with an appraisal of the current status of research and development efforts.

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