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TABLE F-1 Evidence Map for Cancer/Neoplasms

Indicator

Mechanistic Data

Animal Data

Observational Studies

Randomized Trials

Primary Outcome

Secondary or Non–Pre-specified Outcomesa

Calcium

 

 

 

 

 

All cancers

b

b

Breast cancer

Colorectal cancer

b

b

Colorectal adenoma

Prostate cancer

Vitamin D

All cancers

b

Breast cancer

b

Colorectal cancer

b

Colorectal adenoma

b

Prostate cancer

NOTE: = evidence is published; — = no available evidence.

aSecondary outcomes often were not pre-specified by the investigators.

bLimited data.

TABLE F-2 Evidence Map for Cardiovascular Diseases (CVD)/Hypertension

Indicator

Mechanistic Data

Animal Data

Observational Studies

Randomized Trials

Primary Outcome

Secondary or Non–Pre-specified Outcomea

Calcium

b

Vitamin D

b

NOTE: = evidence is published; — = no available evidence.

aSecondary outcomes often were not pre-specified by the investigators.

bLimited data.

TABLE F-3 Evidence Map for Diabetes (Type 2) and Metabolic Syndrome

Indicator

Mechanistic Data

Animal Data

Observational Studies

Randomized Trials

Primary Outcome

Secondary or Non–Pre–specified Outcomesa

Vitamin D

NOTE: = evidence is published; — = no available evidence.

aSecondary outcomes often were not pre-specified by the investigators.



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