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Reference;
Country;
Jadad Score for RCTsb
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Population Description
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Intervention/Duration
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Bone Health Outcomes
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Results
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RCTs
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Greer et al., 1982
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Healthy full-term infants; exclusively breast-fed
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IG1: 400 IU vit D2/d
CG: placebo
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Distal L radius BMC (SPA)
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Serum 25OHD, mean (nmol/L)
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Baseline: no significant difference between groups
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United States
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12 wk:
IG1: 95* (graph)
CG: 50
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n = 18
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12 wk (double-blind)
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Measured at 3, 6, 12, 26, 40, and 52 wks
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Jadad = 3
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66% female
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At 6 mo, unblinded to mother, and placebo group began to receive 400 IU vit D2/d
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17 Caucasian
1 Asian-Indian
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26 wk:
IG1: 81.8
CG: 32.3
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BMC, mean (SEM) (mg/cm)
12 wk: IG1 79 (3); CG 64 (3); p< 0.003
26 wk: IG1 70 (6); CG 75 (5); NS
52 wk: IG1 108 (20); CG 120 (19) (CG receiving vit D for 6 mo)
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Followed to 1 y
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