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Dietary Reference Intakes for Calcium and Vitamin D (2011)
Food and Nutrition Board (FNB)

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. "4 Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D." Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press, 2011.

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DRI Dietary Reference Intakes Calcium Vitamin D

TABLE 4-9 Combined Vitamin D and Calcium and Bone Mineral Density/Bone Mineral Content: Characteristics of RCTs Published after AHRQ-Ottawa Report: Summary from AHRQ-Tufts Analysesa

Reference;

Location (Latitude)

Population Description

Background Calcium Intake and Vitamin D Data

Comparisons

Compliance

Comments

Cheng et al., 2005

Health status: Healthy

Mean age (range), y: 11.2 (10–12)

Male (%): 0

Diet vit D: 100 IU/d

200 IU vit D3/d + 1,000 mg Ca carbonate/d vs. placebo

65% completed intervention with > 50% compliance

 

 

Ca: 670 mg/d

 

Jyvaskyla, Finland (62°24′N)

 

Bolton-Smith et al., 2007

Health status: Healthy (assumed postmenopausal)

Mean age (range), y: 68 (≥ 60)

Male (%): 0

25OHD: 59.4 nmol/L

400 IU vit D3/d + 100 mg elemental Ca/d vs. placebo

Good supplement adherence based on pill count (median, 99; IQE 97.3–99.8%)

Noncompliant women were excluded

 

Ca: 1,548 mg/d

UK (54°N)

Zhu et al., 2008b

Health status: nd (assumed postmenopausal)

Mean age (SD), y: 74.8 (2.6)

Male (%): 0

25OHD: 68 nmol/L

1,000 IU vit D2/d + 1,200 mg Ca citrate/d vs. placebo

No differences in adherence among groups (81–89% by tablet counting)

 

Western Australia

Ca: 1,010 mg/d

 

Moschonis and Manios, 2006

Health status: Postmenopausal

Diet vit D: 23.6 IU/d

300 IU vit D3/d + 1,200 mg Ca/d (from low-fat dairy products) vs. control (usual diet)

Dairy group 93% (assessed via information obtained at the biweekly sessions)

Control group had no intervention (or usual diet), so compliance issue not applicable

Mean age (range), y: 61 (55–65)

Male (%): 0

Ca 680.0 mg/d

Greece (31°N)

 

NOTE: IU = International Units; nd = not determined; SD = standard deviation; UK = United Kingdom; vit = vitamin; y = year(s).

aThis table has been truncated for the purposes of this chapter, but it can be found in its entirety in Appendix D.

SOURCE: Chung et al. (2009).

Page
225
Front Matter (R1-R16)
Summary (1-14)
1 Introduction (15-34)
2 Overview of Calcium (35-74)
3 Overview of Vitamin D (75-124)
4 Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D (125-344)
5 Dietary Reference Intakes for Adequacy: Calcium and Vitamin D (345-402)
6 Tolerable Upper Intake Levels: Calcium and Vitamin D (403-456)
7 Dietary Intake Assessment (457-478)
8 Implications and Special Concerns (479-512)
9 Information Gaps and Research Needs (513-522)
Appendix A: Acronyms, Abbreviations, and Glossary (523-536)
Appendix B: Issues and Interests Identified by Study Sponsors (537-538)
Appendix C: Methods and Results from the AHRQ-Ottawa Evidence-Based Report on Effectiveness and Safety of Vitamin D in Relation to Bone Health (539-724)
Appendix D: Methods and Results from the AHRQ-Tufts Evidence-Based Report on Vitamin D and Calcium (725-1012)
Appendix E: Literature Search Strategy (1013-1018)
Appendix F: Evidence Maps (1019-1024)
Appendix G: Cases Studies of Vitamin D Toxicity (1025-1034)
Appendix H: Estimated Intakes of Calcium and Vitamin D from National Surveys (1035-1044)
Appendix I: Proportion of the Population Above and Below 40 nmol/L Serum 25-Hydroxyvitamin D Concentrations and Cumulative Distribution of Serum 25-Hydroxyvitamin D Concentrations: United States and Canada (1045-1058)
Appendix J: Workshop Agenda and Open Session Agendas (1059-1064)
Appendix K: Biographical Sketches of Committee Members (1065-1074)
Index (1075-1102)
Summary Tables: Dietary Reference Intakes (1103-1116)