Transparency. Methods are explicitly defined, consistently applied, and available for public review so that observers can readily link judgments, decisions, or actions to the data on which they are based. Allows users to assess the strengths and weaknesses of the systematic review or clinical practice guideline.

Users and stakeholders. Refers to individuals who are likely to consult a specific SR to guide decision making or who have a particular interest in the outcome of an SR. This includes consumers, including patients, families, and informal (or unpaid) caregivers; clinicians, including physicians, nurses, and other healthcare professionals; payers; and policy makers, including guideline developers and other SR sponsors.