BOX 2-1

Recommended Standards for Initiating a Systematic Review

Standard 2.1 Establish a team with appropriate expertise and experience to conduct the systematic review

Required elements:

2.1.1

Include expertise in the pertinent clinical content areas

2.1.2

Include expertise in systematic review methods

2.1.3

Include expertise in searching for relevant evidence

2.1.4

Include expertise in quantitative methods

2.1.5

Include other expertise as appropriate

Standard 2.2 Manage bias and conflict of interest (COI) of the team conducting the systematic review

Required elements:

2.2.1

Require each team member to disclose potential COI and professional or intellectual bias

2.2.2

Exclude individuals with a clear financial conflict

2.2.3

Exclude individuals whose professional or intellectual bias would diminish the credibility of the review in the eyes of the intended users

Standard 2.3 Ensure user and stakeholder input as the review is designed and conducted

Required element:

2.3.1

Protect the independence of the review team to make the final decisions about the design, analysis, and reporting of the review

Standard 2.4 Manage bias and COI for individuals providing input into the systematic review

Required elements:

2.4.1

Require individuals to disclose potential COI and professional or intellectual bias

2.4.2

Exclude input from individuals whose COI or bias would diminish the credibility of the review in the eyes of the intended users

Standard 2.5 Formulate the topic for the systematic review

Required elements:

2.5.1

Confirm the need for a new review

plexity of the question(s) being addressed. The number of individuals with a particular expertise needs to be carefully balanced so that one group of experts is not overly influential. For example, review teams that are too dominated by clinical content experts are more likely to hold preconceived opinions related to the topic of the SR,



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