health; and the creation of measures that can follow children and adolescents across different care settings, health plans, and multiple states over time. Clinical and comparative effectiveness research and the Centers of Excellence (U18) awards authorized by the CHIPRA legislation offer two important opportunities to build the evidence base for health care access and quality measures and to fill critical gaps, especially those gaps that address the specific characteristics and needs of younger populations. New initiatives associated with HIT and the creation of EHRs also offer substantial opportunities to foster the incorporation of children and adolescents into efforts to build the next generation of data sources and data collection methods. However, these efforts by themselves are unlikely to achieve this objective. Ultimately, greater alignment among federal agencies concerned with technology and quality measurement will be necessary.