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Di Giorgio et al., 2008
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TBI, moderate lateral fluid percussion TBI
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Adult, male Sprague-Dawley rats
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Pre- and postinjury, curcumin (3, 30, 300 mg/kg), α-tocopherol (100 mg/kg), DMSO (1 ml/kg), or saline (1 ml/kg), 30 minutes prior to injury, then 30 and 90 minutes after injury
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Compared to rats treated with saline, rats that received curcumin (at all 3 dosages), DMSO, and α-tocopherol had significantly less neuron degeneration (p < 0.05). But there was no significant difference between the 3 treatment groups.
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Wu et al., 2006
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TBI, mild fluid percussion injury model
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Male, Sprague-Dawley rats
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Preinjury, regular diet, regular diet with curcumin (500ppm), high-fat diet, or high-fat diet with curcumin (500ppm), for 4 weeks
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Rats on diets without curcumin had significantly higher level of oxidized proteins compared to sham-injured rats (p < 0.01), but rats on diets with curcumin had lower oxidized protein level than sham-injured rats (p < 0.01). Curcumin had no effect on sham-injured rats.
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Injury lowered BDNF level, CREB, synapsin I and phosphorylated-synapsin I expression in the hippocampus (p < 0.05 vs. sham-injured rats on regular diet), but curcumin supplementation restored them to normal level (~100% of sham-injured rats on regular diet). While the 2 diets had no effect on BDNF level in sham-injured rats, curcumin supplementation increased it (p < 0.05 vs. sham-injured rats on regular diet).
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