Type of Injury/Insult

Type of Study and Subjects



Di Giorgio et al., 2008

TBI, moderate lateral fluid percussion TBI

Adult, male Sprague-Dawley rats

Pre- and postinjury, curcumin (3, 30, 300 mg/kg), α-tocopherol (100 mg/kg), DMSO (1 ml/kg), or saline (1 ml/kg), 30 minutes prior to injury, then 30 and 90 minutes after injury

Compared to rats treated with saline, rats that received curcumin (at all 3 dosages), DMSO, and α-tocopherol had significantly less neuron degeneration (p < 0.05). But there was no significant difference between the 3 treatment groups.

Wu et al., 2006

TBI, mild fluid percussion injury model

Male, Sprague-Dawley rats

Preinjury, regular diet, regular diet with curcumin (500ppm), high-fat diet, or high-fat diet with curcumin (500ppm), for 4 weeks

Rats on diets without curcumin had significantly higher level of oxidized proteins compared to sham-injured rats (p < 0.01), but rats on diets with curcumin had lower oxidized protein level than sham-injured rats (p < 0.01). Curcumin had no effect on sham-injured rats.

Injury lowered BDNF level, CREB, synapsin I and phosphorylated-synapsin I expression in the hippocampus (p < 0.05 vs. sham-injured rats on regular diet), but curcumin supplementation restored them to normal level (~100% of sham-injured rats on regular diet). While the 2 diets had no effect on BDNF level in sham-injured rats, curcumin supplementation increased it (p < 0.05 vs. sham-injured rats on regular diet).

Injured rats on diets without curcumin had worse performance in Morris water maze than sham-injured rats (p < 0.05), with injured rats on high-fat diet having the lowest performance (p < 0.05); but the addition of curcumin to diets reversed the effect of TBI on the rats’ performance. Curcumin also increased the swim speed of injured rats on high-fat diet. Performance of sham-injured rats in Morris water maze was not affected by high-fat diet or curcumin.

a n: sample size.

b RR: relative risk.

c CI: confidence interval.

d OR: odds ratio.

e r: correlation coefficient.

f HR: hazard ratio.

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