TABLE 14-2 Relevant Data Identified for Resveratrol

Reference

Type of Injury/Insult

Type of Study and Subjects

Treatment

Findings/Results

Tier 1: Clinical trials

None found

 

 

 

 

Tier 2: Observational studies

None found

 

 

 

 

Tier 3: Animal studies

Sönmez et al., 2007

Percussion TBI model for immature rats

Randomized, placebo-controlled study

Postinjury, a single dose of intraperitoneal resveratrol (100 mg/kg), saline, or no treatment

Locomotor activity in injured rats treated with saline was 38% lower than control rats and 36.2% lower than resveratrol-treated rats (p < 0.01). Performances on discrimination index, used to assess posttraumatic memory, were higher in both control rats (0.65±0.06, p < 0.01) and resveratrol-treated rats (0.43±0.06, p < 0.05) compared to saline-treated rats (0.17±0.07).

7-day-old Wistar albino rat pups

Treatment with resveratrol increased the density of neurons in all ipsilateral and contralateral hippocampal regions in comparison to the injured, saline-treated animals (p < 0.001). There was a significant neuronal loss despite the treatment, however, in the ipsilateral hipoccampal CA1 (p < 0.001), CA2 (p < 0.01), CA3 (p < 0.05), and DG (p < 0.001) regions when compared to control rats.

Ates et al., 2007

TBI model by weight drop technique

Randomized, placebo-controlled study

Postinjury, a single dose of intraperitoneal resveratrol (100 mg/kg), saline, or no treatment

Saline-treated injured rats had increased levels of MDA (p < 0.05), nitric oxide (NO, p < 0.05), and xanthine oxidase (XO, p < 0.05) and decreased levels of gluthatione (GSH, p < 0.05) compared to control rats. But injured rats treated with resveratrol showed reduced levels of MDA (p < 0.05), NO (p < 0.05), and XO (p < 0.05) and increased levels of GSH (p < 0.05).

adult albino male Wistar rats

The resveratrol group also showed significantly lower cerebral edema 24 hours after injury (p < 0.05) and smaller lesion area 14 days after injury (p < 0.05) compared to untreated group.



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