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Sönmez et al., 2007
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Percussion TBI model for immature rats
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Randomized, placebo-controlled study
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Postinjury, a single dose of intraperitoneal resveratrol (100 mg/kg), saline, or no treatment
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Locomotor activity in injured rats treated with saline was 38% lower than control rats and 36.2% lower than resveratrol-treated rats (p < 0.01). Performances on discrimination index, used to assess posttraumatic memory, were higher in both control rats (0.65±0.06, p < 0.01) and resveratrol-treated rats (0.43±0.06, p < 0.05) compared to saline-treated rats (0.17±0.07).
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Treatment with resveratrol increased the density of neurons in all ipsilateral and contralateral hippocampal regions in comparison to the injured, saline-treated animals (p < 0.001). There was a significant neuronal loss despite the treatment, however, in the ipsilateral hipoccampal CA1 (p < 0.001), CA2 (p < 0.01), CA3 (p < 0.05), and DG (p < 0.001) regions when compared to control rats.
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Ates et al., 2007
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TBI model by weight drop technique
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Randomized, placebo-controlled study
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Postinjury, a single dose of intraperitoneal resveratrol (100 mg/kg), saline, or no treatment
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Saline-treated injured rats had increased levels of MDA (p < 0.05), nitric oxide (NO, p < 0.05), and xanthine oxidase (XO, p < 0.05) and decreased levels of gluthatione (GSH, p < 0.05) compared to control rats. But injured rats treated with resveratrol showed reduced levels of MDA (p < 0.05), NO (p < 0.05), and XO (p < 0.05) and increased levels of GSH (p < 0.05).
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