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A Agenda Workshop on Nutrition and Neuroprotection in Military Personnel June 23–24, 2010 VENABLE 575 Seventh St., NW, Washington, DC 20004 Wednesday, June 23, 2010: Day 1 1:30 pm Welcome, Introductions, and Purpose of Open Session John Erdman, Committee Chair SESSION 1: BACKGROUND AND OVERVIEW Objective: To understand possible differences in pathophysiology and metabolic response between acute injury and injury from repeated low-severity events due to blast overpressure. Moderator: Cathy Levenson, Committee on Nutrition, Trauma, and the 1:40 Brain 1:45 Central nervous system (CNS)-related neurotrauma in the military environment Col. Michael Jaffee, M.D., USAF Director, Defense and Veterans Brain Injury Center 2:15 Pathophysiology and mechanisms of neurotrauma: Blast and civilian Mårten Risling, M.D., Ph.D. Associate Professor, Department of Neuroscience Karolinska Institutet, Sweden 259

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260 NUTRITION AND TRAUMATIC BRAIN INJURY 2:45 Recurrent sports-related traumatic brain injury (TBI) and tauopathy Robert Stern, Ph.D. Associate Professor of Neurology Co-Director, Center for the Study of Traumatic Encephalopathy Co-Director, Alzheimer’s Disease Clinical & Research Program Boston University School of Medicine 3:15 Panel Discussion 4:15 Public Comments 4:45 Adjourn Thursday, June 24, 2010: Day 2 8:30 am Welcome John Erdman, Committee Chair SESSION 2: CLINICAL TREATMENT AND REHABILITATION Objectives: • o gain understanding of the acute phase of injury in the civilian world (What T treatments are available in early phases and rehabilitation; long-term strategies?) • o gain understanding of the acute phase of injury in the military (What treatments T are available in early phases and rehabilitation; long-term strategies?) Moderator: Ross Zafonte, Committee on Nutrition, Trauma, and the Brain 8:35 8:40 Clinical management in the field Col. Geoffrey Ling, M.D., Ph.D. Medical Corps, U.S. Army Program Manager, Defense Sciences Office DARPA 9:10 Stateside acute care and rehabilitation Maj. Megumi Vogt, M.D. Medical Corps, U.S. Air Force Deputy Director, TBI Clinical Standards of Care Defense Center of Excellence for Psychological Health and Traumatic Brain Injury SESSION 3: NUTRITIONAL CONSIDERATIONS IN CLINICAL TREATMENT Objective: To gain understanding of existing clinical guidance and standards of practice on nutritional interventions for concussion and other CNS-related neurotrauma treatment and recovery. Moderator: Wayne Askew, Committee on Nutrition, Trauma, and the Brain 9:40 9:45 The perspective of an R.D. working with civilian TBI Natalia Bailey, M.S., R.D., C.D. Neurological Trauma/Surgery ICU Nutrition Support Dietitian Harborview Medical Center University of Washington Level I Trauma Center

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261 APPENDIX A 10:05 The perspective of a neurosurgeon Jamshid Ghajar, M.D., Ph.D., FACS President, Brain Trauma Foundation Clinical Professor of Neurological Surgery Weill Cornell Medical College, Cornell University 10:25 The perspective of an R.D. working in the military environment Maj. Kelli Metzger, R.D. Medical Specialist Corps, U.S. Army Chief, Nutrition Marketing and Integration Services Walter Reed Army Medical Center 10:55 Break 11:10 Panel Discussion 12:10 pm Lunch SESSION 4: ROLE OF NUTRITION IN RESILIENCE AND RECOVERY Objective: To gather information about the state of research on the role of diets, food products, and/or nutritional interventions in the enhancement or impairment of recovery from CNS-related neurotrauma. Moderator: John Erdman, Committee on Nutrition, Trauma, and the Brain 1:10 1:20 The ability of nutrients to promote brain plasticity and cognitive health Fernando Gómez-Pinilla, Ph.D. Professor, Depts. of Neurosurgery and Physiological Science University of California, Los Angeles 1:50 Resolvins and Protectins: Specialized proresolving mediators in inflammation, and organ protection from essential fatty acids Charles Serhan, Ph.D. Director, Center for Experimental Therapeutics and Reperfusion Injury The Simon Gelman Professor of Anesthesia Brigham and Women’s Hospital and Harvard Medical School 2:20 Mechanisms of nutritional neuroprotection: Flavanols Sylvain Doré, Ph.D. Associate Professor of Anesthesiology and Critical Care Medicine, and Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine 2:50 Overview of therapeutics for TBI Edward Hall, Ph.D. Director, Spinal Cord & Brain Injury Research Center Professor of Anatomy & Neurobiology, Neurosurgery, Neurology, and Physical Medicine & Rehabilitation, Chandler Medical Center University of Kentucky 3:20 Panel Discussion 4:20 Public Comments

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262 NUTRITION AND TRAUMATIC BRAIN INJURY Meeting 2 of the Committee on Nutrition, Trauma, and the Brain September 23, 2010 The Keck Center of the National Academies 500 Fifth Street, NW, Washington, DC 20001 Room 205 OPEN SESSION AGENDA 10:00 am Welcome John Erdman Chair, Committee on Nutrition, Trauma, and the Brain 10:05 am The need for glucose control in critically ill patients: Risks and benefits Stanley Nasraway, M.D. Tufts University School of Medicine & Tufts Medical Center 11:05 am Targeting mitochondrial dysfunction following TBI using creatine and fasting Patrick Sullivan, Ph.D. The University of Kentucky Chandler College of Medicine 12:05 pm Nutritional Support of TBI at the VA Stephanie Sands, R.D. James A. Haley Veterans Hospital