D
Workshop Agenda

DAY ONE: OCTOBER 11, 2010

8:00 am

Introduction

 

Lonnie King, D.V.M., M.S., M.A.

Chair, Committee on Lyme Disease and Other Tick-Borne Diseases

Dean, College of Veterinary Medicine

The Ohio State University

8:15 am

A Systems Approach in Understanding Tick-Borne Diseases: People, Animals, and the Ecosystem

 

Richard Ostfeld, Ph.D.

Disease Ecologist

Cary Institute of Ecosystem Studies

8:40 am

Discussion

Surveillance, Spectrum, and Burden of Tick-Borne Diseases

9:00 am

Moderator: Gordon Schutze, M.D.

 

Committee Member, Committee on Lyme Disease and Other Tick-Borne Diseases

Professor and Vice-Chairman for Educational Affairs

Department of Pediatrics

Vice President, Baylor International Pediatric AIDS Initiative

Baylor College of Medicine

Texas Children’s Hospital



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D Workshop Agenda DAY ONE: OCTOBER 11, 2010 8:00 am Introduction Lonnie King, D.V.M., M.S., M.A. Chair, Committee on Lyme Disease and Other Tick- Borne Diseases Dean, College of Veterinary Medicine The Ohio State University 8:15 am A Systems Approach in Understanding Tick-Borne Diseases: People, Animals, and the Ecosystem Richard Ostfeld, Ph.D. Disease Ecologist Cary Institute of Ecosystem Studies 8:40 am Discussion Surveillance, Spectrum, and Burden of Tick-Borne Diseases Moderator: Gordon Schutze, M.D. 9:00 am Committee Member, Committee on Lyme Disease and Other Tick-Borne Diseases Professor and Vice-Chairman for Educational Affairs Department of Pediatrics Vice President, Baylor International Pediatric AIDS Initiative Baylor College of Medicine Texas Children’s Hospital 515

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516 CRITICAL RESEARCH NEEDS IN TICK-BORNE DISEASES 9:05 am Landscape of Lyme Disease: Current Knowledge, Gaps, and Research Needs Gary P. Wormser, M.D. Professor of Medicine Chief, Division of Infectious Diseases Vice-Chairman, Department of Medicine New York Medical College 9:30 am Spectrum of Lyme Disease: Approaches to Understanding Multi-factorial and Multidimensional Diseases Benjamin J. Luft, M.D. Edmund D. Pellegrino Professor Division of Infectious Diseases State University of New York at Stony Brook 9:50 am Discussion 10:10 am Break 10:25 am Clinical Manifestations, Co-infection, and Research Needs of Human Babesiosis: The Increasing Health Burden Peter Krause, M.D. Senior Research Scientist Lecturer in Epidemiology, Microbial Diseases Yale School of Public Health 10:40 am Insights into Ehrlichia & Anaplasma: Surveillance, Co-infection, and Research Needs J. Stephen Dumler, M.D. Professor, Department of Pathology Division of Medical Microbiology Johns Hopkins University School of Medicine 11:00 am Rickettsia Diseases: Spectrum of Disease, Spatial Clustering, At-Risk Populations, and Research Needs Jennifer McQuiston, D.V.M, M.S. National Center for Preparedness, Detection, and Control of Infectious Diseases Centers for Disease Control and Prevention 11:20 am Discussion

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517 APPENDIX D 11:40 am Panel: Disease Surveillance & Co-infection J. Stephen Dumler, Peter Krause, Benjamin J. Luft, Jennifer McQuiston, and Gary P. Wormser 12:15 pm Summation: Unifying Knowledge Gaps and Needs Gordon Schutze LUNCH (45 minutes) 12:25 pm At-Risk Populations and Human Face of Tick-Borne Diseases Moderator: Lonnie King 1:10 pm 1:15 pm Panel: Genetic and Acquired Determinants of Host Susceptibility and Vulnerable Populations David Weber, M.D. Professor of Medicine and Pediatrics, School of Medicine Professor of Epidemiology, School of Public Health University of North Carolina Peter Krause, M.D. Senior Research Scientist Lecturer in Epidemiology Microbial Diseases Yale School of Public Health 1:40 pm Discussion 1:55 pm The Human Face of Tick-Borne Disease Infections Pamela Weintraub Author, Cure Unknown Features Editor, Discover Magazine 2:15 pm Discussion 2:55 pm Break Diagnostics and Diagnosis Moderators: Lynn Gerber, M.D. 3:05 pm Committee Member, Committee on Lyme Disease and Other Tick-Borne Diseases Director, Center for the Study of Chronic Illness and Disability College of Health and Human Services George Mason University

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518 CRITICAL RESEARCH NEEDS IN TICK-BORNE DISEASES David H. Walker, M.D. Committee Member, Committee on Lyme Disease and Other Tick-Borne Diseases Professor and Chair Department of Pathology University of Texas Medical Branch at Galveston 3:10 pm Diagnostics for Lyme Disease: Knowledge Gaps and Needs Maria Aguero-Rosenfeld, M.D. Professor of Pathology Director of Clinical Pathology and Microbiology Laboratory Bellevue Hospital Center 3:30 pm Improved Diagnostics & Novel Approaches to Tick- Borne Disease Infections Juan Olano, M.D. Associate Professor, Department of Pathology Director, Residency Training Program University of Texas Medical Branch Center 3:50 pm Potential Bio-Marker Applications for Lyme Disease: Aligning Multiple Symptoms with Biological Measures Afton Hassett, Psy.D. Associate Research Scientist, Department of Anesthesiology Chronic Pain & Fatigue Research Center University of Michigan Medical School 4:10 pm Discussion 4:40 pm Panel: Challenges for Clinicians in Diagnosis and Management of Chronic Illness Manifestations: Knowledge Gaps Sam T. Donta, M.D. Infectious Disease Specialist Falmouth Hospital, Massachusetts

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519 APPENDIX D Brian Fallon, M.D., M.P.H. Director of the Center for Neuroinflammatory Disorders and Biobehavioral Medicine Director of the Lyme and Tick-Borne Diseases Research Center Columbia University Medical Center Richard F. Jacobs, M.D., F.A.A.P. Robert H. Fiser, Jr., M.D. Endowed Chair in Pediatrics Chairman, Department of Pediatrics University of Arkansas for Medical Sciences President, Arkansas Children’s Hospital Research Institute Matthew Liang, M.D., M.P.H. Professor, Department of Health Policy and Management Harvard School of Public Health 5:20 pm Discussion 5:45 pm Summation Lynn Gerber and David Walker 6:00 pm Adjourn DAY TWO: OCTOBER 12, 2010 8:00 am Introduction Lonnie King Emerging Infections, Tick Biology, and Host-Vector Interactions Moderator: Lonnie King 8:05 am Emerging and Re-Emerging Tick-Borne Infections Ulrike Munderloh, D.V.M., Ph.D. Associate Professor, Department of Entomology University of Minnesota

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520 CRITICAL RESEARCH NEEDS IN TICK-BORNE DISEASES 8:25 am Natural History of Ticks: Evolution, Adaptation and Biology Tom G. Schwan, Ph.D., M.S. Chief, Laboratory of Zoonotic Pathogens Chief, Medical Entomology Section National Institute of Allergy and Infectious Diseases 8:45 am Wildlife and Domestic Hosts: Their Roles in Maintaining, Amplifying Pathogens, and their Changing Dynamics Howard Ginsberg, Ph.D. Research Ecologist United States Geological Survey Professor in Residence, Department of Plant Science University of Rhode Island 9:05 am Discussion 9:20 am Comparative Medical Importance of a One Health Approach to Emerging Tick-borne Diseases Edward Breitschwerdt, D.V.M. Professor of Internal Medicine College of Veterinary Medicine North Carolina State University Adjunct Professor of Medicine Duke University Medical Center 9:40 am Variation of Borrelia Subspecies: Implications for Human Disease James H. Oliver, Jr., Ph.D. Director, Institute of Arthropodology and Parasitology Callaway Professor of Biology Georgia Southern University 10:00 am Discussion 10:20 am Break

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521 APPENDIX D Pathogenesis Moderator: Guy Palmer, D.V.M., Ph.D. 10:30 am Committee Member, Committee on Lyme Disease and Other Tick-Borne Diseases Regents Professor of Pathology and Infectious Diseases The Creighton Chair and Director, School for Global Animal Health Washington State University 10:35 am Pathogenesis of Borrelia burgdorferi Infection and Disease Janis Weis, Ph.D. Professor of Pathology, Department of Pathology University of Utah 10:55 am Duration of Spirochete Infection Following Antibiotic Treatment in Animals Linda Bockenstedt, M.D. Harold W. Jockers Professor of Medicine Department of Rheumatology Yale School of Medicine 11:15 am Discussion 11:30 am Antigenic Variation as a Mechanism for Persistent Borrelia Infection Steven Norris, Ph.D. Greer Professor Vice Chair for Research Pathology & Laboratory Medicine University of Texas, Houston 11:50 am Sequestration as a Mechanism for Persistent Borrelia Infection Stephen Barthold, D.V.M., Ph.D. Distinguished Professor Department of Pathology, Microbiology and Immunology Center of Comparative Medicine School of Veterinary Medicine University of California, Davis

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522 CRITICAL RESEARCH NEEDS IN TICK-BORNE DISEASES 12:10 pm Discussion LUNCH (45 minutes) 12:30 pm 1:15 pm Pathogenesis of Ehrlichia and Anaplasma Infection and Disease Nahed Ismail, M.D., M.Sc., Ph.D., S.M. (ASCP), D. (ABMM) Associate Professor, Department of Pathology Meharry Medical College 1:35 pm Pathogenesis of Rickettsia Infection and Disease Gustavo Valbuena, M.D. Instructor, Department of Pathology University of Texas Medical Branch 1:55 pm Discussion 2:15 pm Summation Guy Palmer Science, Society, and Disease Moderator: Lynn Gerber 2:20 pm 2:25 pm The Social Construction of Lyme Disease Robert Aronowitz, M.D. Professor, Department of History and Sociology of Science University of Pennsylvania 2:45 pm Discussion 2:55 pm Break Prevention Moderator: Stephen M. Ostroff, M.D. 3:05 pm Committee Member, Committee on Lyme Disease and Other Tick-Borne Diseases Director, Bureau of Epidemiology Pennsylvania Department of Health

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523 APPENDIX D 3:10 pm Current Vaccines for Tick-Borne Disease Infections and Vaccine Development Jere McBride, Ph.D., M.S. Associate Professor, Department of Pathology University of Texas Medical Branch 3:30 pm Developing Opportunities for Future Vaccines Wendy Brown, Ph.D., M.P.H. Regents Professor, Department of Veterinary Microbiology and Pathology Washington State University 3:50 pm Discussion 4:10 pm Education, Behavior Change, and Other Non- Pharmaceutical Measures Against Lyme and Other Tick- Borne Diseases Paul Mead, M.D., M.P.H. Medical Epidemiologist, Division of Vector-Borne Infectious Diseases National Center for Infectious Diseases Center for Disease Control and Prevention 4:30 pm Vector- and Host-Targeted Strategies for Prevention of Tick-Borne Diseases José M.C. Ribeiro, M.D., Ph.D. Chief, Vector Biology Section Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases 4:50 pm Discussion 5:10 pm Summation Steve Ostroff

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524 CRITICAL RESEARCH NEEDS IN TICK-BORNE DISEASES Closing Moderator: Lonnie King 5:20 pm 5:25 pm Panel: State of Science, General Research Gaps and Opportunities in Tick-Borne Diseases John Aucott, M.D. Founder, Lyme Disease Research Foundation of Maryland Physician, Park Medical Associates Linda Bockenstedt, M.D. Harold W. Jockers Professor of Medicine Department of Rheumatology Yale School of Medicine J. Stephen Dumler, M.D. Professor, Department of Pathology Division of Medical Microbiology Johns Hopkins University School of Medicine Susan O’Connell, M.D. Consultant Microbiologist Head of the Lyme Borreliosis Unit Southampton General Hospital Gregg P. Skall, J.D. Counsel, National Capital Lyme and Tick-borne Disease Association Member, Womble Carlyle Sandridge & Rice, PLLC 5:55 pm Discussion 6:25 pm Final Summation and Closing Remarks Lonnie King 6:35 pm Adjourn