SUMMARY

In summary, when the review of studies used in the draft IRIS assessment of formaldehyde is compared with the current standard for evidence-based reviews and causal inference, limitations in each step used to generate the draft IRIS assessment are evident. For example, the methods are not clearly described, the review approaches are not transparent, and there is no indication that evidence-grading strategies were uniformly applied. In addition, the selection approach to identifying studies for RfC calculation appears ad hoc. The committee emphasizes that it is not recommending that EPA add an extensive discussion of its guidelines to the draft IRIS assessment. It is recommending that key factors used to exclude, include, or advance studies be discussed.

REFERENCES

EPA (U.S. Environmental Protection Agency). 2010a. Frequent Questions: What is IRIS? Integrated Risk Information System, U.S. Environmental Protection Agency, Washington DC [online]. Available: http://www.epa.gov/IRIS/help_ques.htm#whatiris [accessed Dec. 28, 2010].

EPA (U.S. Environmental Protection Agency). 2010b. Toxicological Review of Chloroprene (CAS No. 126-99-8). In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-09/01F. U.S. Environmental Protection Agency, Washington, DC. September 2010 [online]. Available: http://www.epa.gov/iris/toxreviews/1021tr.pdf [accessed Jan. 6, 2010].

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NRC (National Research Council). 2010. Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene. Washington, DC: National Academies Press.

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