sometimes the tracheobronchial tree; the toxin produces degeneration in peripheral nerves, heart muscle, and other tissues; diphtheria had a high fatality rate, especially in children, but is now rare because of an effective vaccine.1

Disseminated varicella: The spreading of the vesicular rash beyond the dermatome involved in the vaccination.5

Embolism: Obstruction or occlusion of a vessel by an embolus.1

Encephalitis: Irritation and swelling (inflammation) of the brain, most often due to infections.2

Encephalopathy: A general term describing brain dysfunction. Examples include encephalitis, meningitis, seizures, and head trauma.5

Erythema nodosum: A panniculitis marked by the sudden formation of painful nodes on the extensor surfaces of the lower extremities, with lesions that are self-limiting but tend to recur; associated with arthralgia and fever; may be the result of drug sensitivity or associated with sarcoidosis and various infections.1

Febrile convulsions: A brief seizure, lasting less than 15 minutes, seen in a neurologically normal infant or young child, associated with fever.1

Fibromyaligia: A chronic disorder characterized by widespread pain, tenderness, and stiffness of muscles and associated connective tissue structures that is typically accompanied by fatigue, headache, and sleep disturbances.3

Guillain-Barré syndrome (GBS): An acute, immune-mediated disorder of peripheral nerves, spinal roots, and cranial nerves, commonly presenting as a rapidly progressive, areflexive, relatively symmetric ascending weakness of the limb, truncal, respiratory, pharyngeal, and facial musculature, with variable sensory and autonomic dysfunction; typically reaches its nadir within 2–3 weeks, followed initially by a plateau period of similar duration, and then subsequently by gradual but complete recovery in most cases.1

Hearing loss: A reduction in the ability to perceive sound; may range from slight inability to complete deafness.1

Hepatitis: Inflammation of the liver, due usually to viral infection but sometimes to toxic agents.1

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