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Adverse Effects of Vaccines: Evidence and Causality (2012)

Chapter: Appendix B: List of Adverse Events

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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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TABLE B-1 Adverse Events Included in the Vaccine Chapters

Adverse Event MMR Vaccine Chapter 4 Varicella Vaccine Chapter 5 Influenza Vaccine Chapter 6 Hepatitis A Vaccine Chapter 7 Hepatitis B Vaccine Chapter 8 HPV Vaccine Chapter 9 DT–, TT–, and aP–Containing Vaccines Chapter 10 Meningococcal Vaccine Chapter 11 Injected-Related Events Chapter 12
Disseminated Oka VZV without Other Organ Involvement

Disseminated Oka VZV with Subsequent Infection Resulting in Pneumonia, Meningitis, or Hepatitis

Vaccine Strain Viral Reactivation without Other Organ Involvement

Vaccine Strain Viral Reactivation with Subsequent Infection Resulting in Meningitis or Encephalitis

Measles Inclusion Body Encephalitis

Encephalitis

Encephalopathy

Infantile Spasms

Seizures

Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Meningitis

Cerebellar Ataxia

Ataxia

Autism

Acute Disseminated Encephalomyelitis

Transverse Myelitis

Optic Neuritis

Neuromyelitis Optica

Multiple Sclerosis

First Demyelinating Event

Guillain-Barré Syndrome

Chronic Inflammatory Disseminated Polyneuropathy

Opsoclonus Myoclonus Syndrome

Bell’s Palsy

Brachial Neuritis

Amyotrophic Lateral Sclerosis

Small Fiber Neuropathy

Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
×
Adverse Event MMR Vaccine Chapter 4 Varicella Vaccine Chapter 5 Influenza Vaccine Chapter 6 Hepatitis A Vaccine Chapter 7 Hepatitis B Vaccine Chapter 8 HPV Vaccine Chapter 9 DT–, TT–, and aP–Containing Vaccines Chapter 10 Meningococcal Vaccine Chapter 11 Injected-Related Events Chapter 12
Anaphylaxis

Chronic Urticaria

Serum Sickness

Asthma

Erythema Nodosum

Systemic Lupus Erythematous

Vasculitis

Polyarteritis Nodosa

Psoriatic Arthritis
Reactive Arthritis

Rheumatoid Arthritis

Juvenile Idiopathic Arthritis

Arthropathy (Arthralgia and Arthritis)

Type 1 Diabetes

Hepatitis (Autoimmune)

Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Myocarditis

Pancreatitis

Hepatitis

Thromboembolic Events

Stroke

Hypercoagulable States

Myocardial Infarction

Chronic Fatigue Syndrome

Chronic Headaches

Fibromyalgia

Sudden Infant Death Syndrome

Hearing Loss

All-Cause Mortality

Oculorespiratory Syndrome

Thrombocytopenia

Immune Thrombocytopenic Purpura

Complex Regional Pain Syndrome

Deltoid Bursitis

Syncope

NOTE: Adverse events indicated by “” were added to the list by the committee.

Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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Suggested Citation:"Appendix B: List of Adverse Events." Institute of Medicine. 2012. Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academies Press. doi: 10.17226/13164.
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In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children.

Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma.

Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

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