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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This project was supported by contracts between the National Academy of Sciences and Robert Wood Johnson Foundation, Grant No. 66737; The California Endowment, Grant No. 20091397; DHHS/CDC, Contract No. 200-2005-13434; and DHHS/NIH, Contract No. N01-OD-4-2139. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

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